课题基金 / 基金详情

FAMILIES WITH GENETIC SUSCEPTIBILITY TO BREAST CANCER

FAMILIES WITH GENETIC SUSCEPTIBILITY TO BREAST CANCER
有乳腺癌遗传易感性的家庭
批准号：
6244530
负责人：
SOFIA DIANA MERAJVER
金额：
$2.22万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-20 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6244530
关键词：
brca gene breast neoplasms cancer risk clinical research family genetics gene expression gene mutation human genetic material tag human subject neoplasm /cancer genetics

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中文摘要
翻译
BRCA 1是一个可能的肿瘤抑制基因，位于染色体17q21上， 有85%的终生乳房和/或卵巢发育风险 携带BRCA1种系突变的妇女罹患癌症。隔离的原因 BRCA1可能会提供对乳腺癌生物学的洞察，因为 以及导致乳房遗传易感性的预测性测试 癌症。来自明显常染色体家系的永生化淋巴细胞 乳腺癌的显性传播是我们的 努力确定BRCA1。
英文摘要
BRCA 1 is a putative tumor suppressor gene located on chromosome 17q21, conferring an 85% lifetime risk of developing breast and/or ovarian cancer on women carrying BRCA1 germline mutations. The isolation of BRCA1 will likely provide insight into the biology of breast cancer as well as lead to predictive testing for genetic susceptibility to breast cancer. Immortalized lymphocytes from families with apparent autosomal dominant transmission of breast cancer are essential reagents in our efforts to identify BRCA1.
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