SANDIMMUNE AND OG37 325 IN PREVENTION OF RENAL ALLOGRAFT REJECTION

SANDIMUNE 和 OG37 325 预防肾同种异体移植排斥

• 批准号: 5216169
• 负责人: ALAN B LEICHTMAN
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5216169
• 关键词: clearance rate; clinical research; cyclosporines; cytochrome P450; drug screening /evaluation; enzyme activity; human subject; human therapy evaluation; kidney function; kidney transplantation; transplant rejection

This protocol provided for the determination of iothalamate and iohexol renal clearances and hepatic cytochrome P450 3A enzyme activity in patients participating in a phase-III multicenter trial comparing the safety and efficacy of the cyclosporin analog, OG 37-325, to that of cyclosporin A in recipients of first renal transplants.

该方案用于测定碘酞酸盐和碘海醇 肾清除率和肝细胞色素 P450 3A 酶活性 参加一项 III 期多中心试验的患者比较 环孢菌素类似物 OG 37-325 的安全性和有效性 首次肾移植受者中的环孢菌素 A。