The Mayo Clinic NeuroNEXT Clinical Research Site

梅奥诊所每年服务约130万名患者，在临床研究和临床试验方面有着卓越的历史。其最先进的研究设施位于明尼苏达州罗切斯特市、佛罗里达州杰克逊维尔市和亚利桑那州斯科茨代尔市，能够在美国中西部北部、东南部和西南部进行协调的临床试验。神经内科拥有200多名儿童和成人神经科医生，拥有一个企业范围的领导结构，支持其综合实践、研究和教育使命。梅奥神经病学诊所每年为近90000名成人和儿童患者提供护理，并拥有强大的临床研究企业。该系教师在包括罕见和超罕见疾病在内的全谱神经系统疾病方面具有临床专业知识和临床试验经验。梅奥诊所的理想定位是为NeuroNEXT提供各种未满足需求的患者和具有这些疾病专业知识的临床试验人员。研究者发起的临床试验将由梅奥神经病学学院直接向NeuroNEXT资助机制。这项拨款申请旨在通过提供基础设施来支持、扩展和创新梅奥诊所所有地点的神经科学临床试验活动，以确保在NeuroNEXT内进行强大的整合，同时利用我们的机构优势。此外，这笔拨款将支持一个创新项目，以培养下一代临床试验人员，使其在创新试验设计和现代监管科学的不断发展的环境中茁壮成长。

Mayo Clinic, which serves ~1.3M patients annually, has a history of excellence in clinical research and clinical trials. Its state-of-the-art research facilities in Rochester, Minnesota, Jacksonville, Florida, and Scottsdale, Arizona enable coordinated clinical trials in the upper Midwest, Southeast, and Southwest United States. The Department of Neurology, which has over 200 child and adult neurologists, has an enterprise-wide leadership structure that supports its integrated practice, research, and education mission. Mayo Clinic Neurology cares for >90,000 adult and pediatric patients annually and has a robust clinical research enterprise. Departmental faculty have clinical expertise and clinical trial experience across the full spectrum of neurological diseases, including rare and ultra-rare conditions. Mayo Clinic is ideally positioned to provide NeuroNEXT the diverse patients with unmet needs and the clinical trialists with expertise in these diseases. Investigator-initiated clinical trials by Mayo neurology faculty will be directed towards NeuroNEXT funding mechanisms. This grant application aims to support, expand, and innovate neuroscience clinical trial activities at all Mayo Clinic sites by providing the infrastructure to ensure robust integration within NeuroNEXT, while leveraging our institutional strengths. Furthermore, the grant will support an innovative program to train the next generation of clinical trialists to thrive in an evolving landscape of innovative trial design and modern regulatory science.