SPATIALLY ORIENTED DATABASE FOR DIGITAL BRAIN IMAGES

数字脑图像的空间导向数据库

• 批准号: 2442325
• 负责人: Edward H Herskovits
• 金额: $ 24.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2442325
• 关键词: brain imaging /visualization /scanning; computational neuroscience; computer system design /evaluation; digital imaging; human data; image processing; information system analysis; information systems; neuroanatomy; statistics /biometry

DESCRIPTION (Adapted from applicant's abstract): The overall goal of this project is the conceptual development and prototype implementation of a database methodology that supports the archiving and statistical investigation of large numbers and types of brain images. The specific aims of the study are: 1) to develop a morphologically factored image representation (MFIR) system that allows improved comparison of brain images, 2) to develop a BRAin Image Database (BRAID) that supports novel statistical analyses of image datasets, and 3) to evaluate the database by applying it to both simulated data and to real data from 3 current brain imaging studies. The MFIR is based on a nonlinear registration of an image to a standard Atlas to create a morphologically normalized signal component and a morphological variation component, represented as a displacement vector field in Atlas coordinates. The BRAID will implement storage, query and statistical operations on the MFIR components. The BRAID will be validated by testing its ability to recover known correlations from simulated data, and applied to the analysis of data from several collaborating epidemiological studies. The applications will test the system's ability to identify brain structure/function correlations from lesion/deficit data derived from stroke and injury, and its ability to identify patterns of morphological change in brain anatomy with age, and correlate these with functional data. Stroke data will be provided by the Cardiovascular Health Study, and NHLBI sponsored project that is collecting extensive prospective demographic, functional, and brain MRI data on over 3,600 participants. Injury data will be collected by the Psychopathology of Frontal Lobe Injury in Childhood study, which is collecting brain MRI and extensive psychiatric/functional data on 100 children with traumatic brain injuries. Aging-related morphological and functional change data will be supplied by Baltimore Longitudinal Study on Aging, which follows 180 patients over a 9 year period and performs MRI and PET scans, along with neurofunctional evaluations, on an annual basis. The newly developed database is intended to be flexible in terms of acceptable data types, robust in its querying mechanisms and extendable to other laboratories; thus providing the basis of a future broad based, multi-institutional brain informatics network.

描述（改编自申请人摘要）：总体目标 本项目是概念开发和原型实现 数据库方法，支持存档和统计 研究大量和类型的大脑图像。具体 研究的目的是：1）开发一个形态因子图像 MFIR表示系统，允许改进的比较大脑 图像，2）开发一个BRAin图像数据库（BRAID），支持新的 图像数据集的统计分析，以及3）评估数据库 通过将其应用于来自3个电流的模拟数据和真实的数据， 脑成像研究。 MFIR基于图像与标准图像的非线性配准， 图谱，以创建形态标准化的信号分量和 形态变化分量，表示为位移向量 在阿特拉斯坐标系中。BRAID将实现存储、查询和 MFIR组件上的统计操作。BRAID将是 通过测试其恢复已知相关性的能力， 模拟数据，并应用于数据分析，从几个 合作进行流行病学研究。应用程序将测试 系统识别大脑结构/功能相关性的能力， 来自中风和损伤的病变/缺损数据，以及其 识别大脑解剖学中随年龄变化的形态学变化模式，以及 将这些与功能数据相关联。卒中数据将由 心血管健康研究和NHLBI赞助的项目， 收集广泛的前瞻性人口统计学、功能和脑MRI 超过3，600名参与者的数据。受伤数据将由 儿童额叶损伤的精神病理学研究， 收集100名患者的脑部MRI和广泛的精神/功能数据， 患有创伤性脑损伤的儿童衰老相关的形态学和 功能变化数据将由巴尔的摩纵向研究提供 在9年的时间里，对180名患者进行了跟踪调查， MRI和PET扫描，沿着神经功能评估，每年进行一次 基础新开发的数据库旨在灵活地 可接受的数据类型，查询机制健壮， 可扩展到其他实验室;从而为未来的 基础广泛的多机构脑信息学网络。