NEOPLASTIC LEUKOCYTES

计划中的研究将是正在进行的项目的延续， 反映了人类对异常生长调节的长期兴趣 造血系统。 1.染色体和分子研究相结合，卡洛·克罗奇博士和 其他的，涉及人类淋巴系和髓系的特定基因 肿瘤和导致基因功能改变的机制。 2.慢性B细胞和T细胞的纵向细胞遗传学研究 与临床、生物学和免疫学相关的疾病 这些肿瘤的特征。 3.慢性B细胞生长调节改变的进一步研究 和T细胞疾病，包括抑制因子(转化生长 因子-β)、刺激因子和自身反应性在 B-CLL。 (这笔赠款是宾夕法尼亚大学癌症分校的一部分 居中)

The planned studies will be a continuation of ongoing projects that reflect a long interest in abnormal growth regulation in the human hematopoietic system. 1. Combined chromosomal and molecular studies, with Dr. Carlo Croce and others, of specific genes involved in human lymphoid and myeloid neoplasms and mechanisms leading to altered gene function. 2. Longitudinal cytogenetic studies in chronic B cell and T cell disorders correlated with clinical, biological, and immunological characteristics of these neoplasms. 3. Further investigation of altered growth regulation in chronic B cell and T cell disorders, including inhibitory factors (transforming growth factor-beta), stimulatory factors, and the role of autoreactivity in B-CLL. (This grant is a component of the University of Pennsylvania Cancer Center)