课题基金 / 基金详情

NEOPLASTIC LEUKOCYTES

NEOPLASTIC LEUKOCYTES
肿瘤性白细胞
批准号:
2882336
负责人:
PETER C NOWELL
金额:
$61.04万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-05-10 至 2001-02-28

项目摘要

项目成果

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中文摘要
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英文摘要
The planned studies will be a continuation of ongoing projects that reflect a long interest in abnormal growth regulation in the human hematopoietic system. 1. Combined chromosomal and molecular studies, with Dr. Carlo Croce and others, of specific genes involved in human lymphoid and myeloid neoplasms and mechanisms leading to altered gene function. 2. Longitudinal cytogenetic studies in chronic B cell and T cell disorders correlated with clinical, biological, and immunological characteristics of these neoplasms. 3. Further investigation of altered growth regulation in chronic B cell and T cell disorders, including inhibitory factors (transforming growth factor-beta), stimulatory factors, and the role of autoreactivity in B-CLL. (This grant is a component of the University of Pennsylvania Cancer Center)
期刊论文(49)
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会议论文
Regulation of gene expression in lectin-stimulated or lymphokine-stimulated T lymphocytes. Effects of cyclosporine.
凝集素刺激或淋巴因子刺激的 T 淋巴细胞中基因表达的调节。
DOI: 10.1097/00007890-198808001-00016
发表时间: 1988
期刊: Transplantation
影响因子: 6.2
作者: [Reed,JC, Prystowsky,MB, Nowell,PC]
通讯作者: Nowell,PC
Evidence for early hematopoietic progenitor cell involvement in acute promyelocytic leukemia.
早期造血祖细胞参与急性早幼粒细胞白血病的证据。
DOI: 10.1093/ajcp/112.6.819
发表时间: 1999
期刊: American journal of clinical pathology
影响因子: 3.5
作者: [Edwards,RH, Wasik,MA, Finan,J, Rodriguez,R, Moore,J, Kamoun,M, Rennert,H, Bird,J, Nowell,PC, Salhany,KE]
通讯作者: Salhany,KE
Altered response to and production of TGF-beta by B cells from autoimmune NZB mice.
自身免疫 NZB 小鼠 B 细胞对 TGF-β 的反应和产生发生改变。
DOI: 10.1006/cimm.1997.1149
发表时间: 1997
期刊: Cellular immunology
影响因子: 4.3
作者: [Douglas,RS, Woo,EY, Capocasale,RJ, Tarshis,AD, Nowell,PC, Moore,JS]
通讯作者: Moore,JS
DOI: 10.1182/blood.v90.12.4679.4679_4679_4686
发表时间: 1997-12-15
期刊: BLOOD
影响因子: 20.3
作者: [Felix, CA, Kim, CS, Rappaport, EF]
通讯作者: Rappaport, EF
32
    STUDIES OF NEOPLASTIC AND NORMAL LEUKOCYTES
    • 批准号:
      3479291
    • 项目类别:
    • 资助金额:
      $66.02万
    • 财政年份:
      1986
    • 负责人:
      PETER C NOWELL
    • 依托单位:
    STUDIES OF NEOPLASTIC AND NORMAL LEUKOCYTES
    • 批准号:
      3479292
    • 项目类别:
    • 资助金额:
      $63.98万
    • 财政年份:
      1986
    • 负责人:
      PETER C NOWELL
    • 依托单位:
    NEOPLASTIC AND NORMAL LEUKOCYTES
    • 批准号:
      3479294
    • 项目类别:
    • 资助金额:
      $72.98万
    • 财政年份:
      1986
    • 负责人:
      PETER C NOWELL
    • 依托单位:
    NEOPLASTIC LEUKOCYTES
    • 批准号:
      2376798
    • 项目类别:
    • 资助金额:
      $57.96万
    • 财政年份:
      1986
    • 负责人:
      PETER C NOWELL
    • 依托单位:
    海外基金