NEOPLASTIC LEUKOCYTES
NEOPLASTIC LEUKOCYTES
批准号:
2882336
负责人:
PETER C NOWELL
金额:
$61.04万
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-05-10 至 2001-02-28
关键词:
cell growth regulation chronic leukemia cytogenetics gene expression hematopoiesis human genetic material tag human subject hybrid cells interleukin 5 lymphocytic leukemia lymphoma molecular cloning myelogenous leukemia neoplasm /cancer genetics neoplasm /cancer immunology neoplastic cell northern blottings oncogenes preneoplastic state transforming growth factors tumor suppressor genes
中文摘要
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英文摘要
The planned studies will be a continuation of ongoing projects that
reflect a long interest in abnormal growth regulation in the human
hematopoietic system.
1. Combined chromosomal and molecular studies, with Dr. Carlo Croce and
others, of specific genes involved in human lymphoid and myeloid
neoplasms and mechanisms leading to altered gene function.
2. Longitudinal cytogenetic studies in chronic B cell and T cell
disorders correlated with clinical, biological, and immunological
characteristics of these neoplasms.
3. Further investigation of altered growth regulation in chronic B cell
and T cell disorders, including inhibitory factors (transforming growth
factor-beta), stimulatory factors, and the role of autoreactivity in
B-CLL.
(This grant is a component of the University of Pennsylvania Cancer
Center)
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Regulation of gene expression in lectin-stimulated or lymphokine-stimulated T lymphocytes. Effects of cyclosporine.
凝集素刺激或淋巴因子刺激的 T 淋巴细胞中基因表达的调节。
DOI:
10.1097/00007890-198808001-00016
发表时间:
1988
期刊:
Transplantation
影响因子:
6.2
作者:
[Reed,JC, Prystowsky,MB, Nowell,PC]
通讯作者:
Nowell,PC
Evidence for early hematopoietic progenitor cell involvement in acute promyelocytic leukemia.
早期造血祖细胞参与急性早幼粒细胞白血病的证据。
DOI:
10.1093/ajcp/112.6.819
发表时间:
1999
期刊:
American journal of clinical pathology
影响因子:
3.5
作者:
[Edwards,RH, Wasik,MA, Finan,J, Rodriguez,R, Moore,J, Kamoun,M, Rennert,H, Bird,J, Nowell,PC, Salhany,KE]
通讯作者:
Salhany,KE
Altered response to and production of TGF-beta by B cells from autoimmune NZB mice.
自身免疫 NZB 小鼠 B 细胞对 TGF-β 的反应和产生发生改变。
DOI:
10.1006/cimm.1997.1149
发表时间:
1997
期刊:
Cellular immunology
影响因子:
4.3
作者:
[Douglas,RS, Woo,EY, Capocasale,RJ, Tarshis,AD, Nowell,PC, Moore,JS]
通讯作者:
Moore,JS
DOI:
10.1182/blood.v90.12.4679.4679_4679_4686
发表时间:
1997-12-15
期刊:
BLOOD
影响因子:
20.3
作者:
[Felix, CA, Kim, CS, Rappaport, EF]
通讯作者:
Rappaport, EF
Trisomy 3 in cold agglutinin disease.
冷凝集素病中的三体性 3。
DOI:
10.1016/0165-4608(90)90013-z
发表时间:
1990
期刊:
Cancer genetics and cytogenetics
影响因子:
--
作者:
[Gordon,J, Silberstein,L, Moreau,L, Nowell,PC]
通讯作者:
Nowell,PC
共 32 条
STUDIES OF NEOPLASTIC AND NORMAL LEUKOCYTES
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批准号:3479291
-
项目类别:
-
资助金额:$66.02万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
STUDIES OF NEOPLASTIC AND NORMAL LEUKOCYTES
-
批准号:3479292
-
项目类别:
-
资助金额:$63.98万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
NEOPLASTIC AND NORMAL LEUKOCYTES
-
批准号:3479294
-
项目类别:
-
资助金额:$72.98万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
NEOPLASTIC LEUKOCYTES
-
批准号:2376798
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项目类别:
-
资助金额:$57.96万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
NEOPLASTIC LEUKOCYTES
-
批准号:2090635
-
项目类别:
-
资助金额:$53.95万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
NEOPLASTIC LEUKOCYTES
-
批准号:3479288
-
项目类别:
-
资助金额:$49.58万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
STUDIES OF NEOPLASTIC AND NORMAL LEUKOCYTES
-
批准号:3479286
-
项目类别:
-
资助金额:$55.68万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
STUDIES OF NEOPLASTIC AND NORMAL LEUKOCYTES
-
批准号:3479289
-
项目类别:
-
资助金额:$59.3万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
STUDIES OF NEOPLASTIC AND NORMAL LEUKOCYTES
-
批准号:3479290
-
项目类别:
-
资助金额:$62.49万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
STUDIES OF NEOPLASTIC AND NORMAL LEUKOCYTES
-
批准号:3479293
-
项目类别:
-
资助金额:$63.02万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
NEOPLASTIC LEUKOCYTES
-
批准号:2090634
-
项目类别:
-
资助金额:$50.79万
-
财政年份:1986
-
负责人:PETER C NOWELL
-
依托单位:
NEOPLASTIC LEUKOCYTES
-
批准号:2090636
-
项目类别:
-
资助金额:$56.11万
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财政年份:1986
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负责人:PETER C NOWELL
-
依托单位:
NEOPLASTIC LEUKOCYTES
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批准号:2667889
-
项目类别:
-
资助金额:$59.47万
-
财政年份:1986
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负责人:PETER C NOWELL
-
依托单位:
CHROMOSOME TRANSLOCATIONS AND IG GENES IN HUMAN LEUKEMIA
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批准号:3172811
-
项目类别:
-
资助金额:$12.81万
-
财政年份:1983
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负责人:PETER C NOWELL
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依托单位:
IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTES
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批准号:3092675
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项目类别:
-
资助金额:$89.24万
-
财政年份:1979
-
负责人:PETER C NOWELL
-
依托单位:
LEUKOCYTE REGULATORY MECHANISMS
-
批准号:3163680
-
项目类别:
-
资助金额:$14.85万
-
财政年份:1977
-
负责人:PETER C NOWELL
-
依托单位:
LEUKOCYTE REGULATORY MECHANISMS
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批准号:3163679
-
项目类别:
-
资助金额:$2.62万
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财政年份:1977
-
负责人:PETER C NOWELL
-
依托单位:
LYMPHOCYTE POPULATION IN CHRONIC LYMPHOCYTIC LEUKEMIA
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批准号:4690561
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:PETER C NOWELL
-
依托单位:
海外基金