STUDIES OF A NOVEL TYROSINE KINASE IN MEGAKARYOCYTES

巨核细胞中新型酪氨酸激酶的研究

• 批准号: 2519390
• 负责人: HAVA Karsenty AVRAHAM
• 金额: $ 33.53万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2519390
• 关键词: CD antigens; DNA binding protein; Escherichia coli; HIV infections; antisense nucleic acid; biological signal transduction; cell cycle; cell differentiation; cell growth regulation; complementary DNA; cytokine receptors; genetic regulation; genetic regulatory element; genetic transcription; human subject; immunocytochemistry; laboratory rabbit; megakaryocytes; messenger RNA; monoclonal antibody; phorbols; phosphorylation; protein tyrosine kinase; recombinant proteins; transfection

One of the key manifestations in HIV infection is thrombocytopenia which was described even prior to the discovery of HIV. This grantee is investigating the role of various gene products in regulation of megakaryocytopoiesis and the effect of HIV infection on megakaryocytic cells. One such gene product, termed megakaryocyte associated tyrosine kinase, will be studied with respect to its expression in HIV infection. Initial results indicated an inhibitory effect of HIV on expression of these genes. The results of these studies will provide one mechanism for retroviral impairment of megakaryocyte growth and maturation.

艾滋病毒感染的关键表现之一是血小板减少症 甚至在发现艾滋病毒之前就被描述了。 这个受赠人是 研究各种基因产物在调节中的作用 巨核细胞质和艾滋病毒感染对巨核细胞的影响 细胞。 一种这样的基因产品，称为巨核细胞相关酪氨酸 激酶将研究其在HIV感染中的表达。 初始结果表明HIV对表达的抑制作用 这些基因。 这些研究的结果将为 大核细胞生长和成熟的逆转录病毒损害。