ARE P27 AND P21 TUMOR SUPPRESSORS

P27和p21是两个最近被发现的 发现的蛋白质，导致G1阻滞细胞周期的进展， 对抗有丝分裂刺激的反应。 消除细胞周期检查点 由这些分子介导的可能有助于细胞 转化或肿瘤进展。 Fero博士是一位肿瘤学家， 他在华盛顿大学的医学训练和弗雷德哈钦森 癌症研究中心，已经创造了转基因小鼠，以测试这些 假设 将对这些小鼠进行研究，以评估总体表型 p27和p21破坏单独和联合作用。 的 这些小鼠对乳腺和皮肤肿瘤发展的易感性， 无论是自发的还是接触致癌物质后， 测定 该项目涉及来自基础科学院的科学家合作， 哈钦森中心的科学和公共卫生部门， 科学家在血液学和生物化学部门的大学， 华盛顿。 费罗博士将通过以下方式进一步提高他的基础科学背景： 将分子遗传学和生物统计学课程结合到他的研究中 程序. 他的目标是开发转基因动物模型， 解开细胞周期调控的奥秘，并将有助于 开发新类型的癌症治疗剂。

DESCRIPTION (Applicant's Description): P27 and p21 are two recently discovered proteins which cause a G1 block to cell cycle progression in response to antimitogenic stimuli. Elimination of cell cycle checkpoints mediated by molecules such as these may contribute to cellular transformation or tumor progression. Dr. Fero, an oncologist who completed his medical training at the University of Washington and the Fred Hutchinson Cancer Research Center, has created transgenic mice in order to test these hypotheses. These mice will be studied to assess the overall phenotypic effect of p27 and p21 disruption alone and in combination. The susceptibility of these mice to the development of mammary and skin tumors, both spontaneously and following exposure to carcinogens, will then be determined. The project involves collaboration of scientists from the Basic Sciences and Public Health divisions of the Hutchinson Center with scientists at the Hematology and Biochemistry divisions of the University of Washington. Dr. Fero will enhance his basic science background further by combining molecular genetics and biostatistics coursework to his research program. His goals are to develop transgenic animal models which help to unravel the mysteries of cell cycle regulation and will contribute to the development of new classes of cancer therapeutic agents.