ARE P27 AND P21 TUMOR SUPPRESSORS

描述(申请人描述)：p27和p21是最近的两个 发现了导致G1期细胞周期进展受阻的蛋白质 对抗分裂刺激的反应。消除细胞周期检查点 由这样的分子介导的可能有助于细胞 转化或肿瘤进展。费罗博士是一位肿瘤学家，他完成了 他在华盛顿大学和弗雷德·哈钦森大学接受的医学训练 癌症研究中心已经创造了转基因小鼠来测试这些 假设。将对这些小鼠进行研究，以评估总体表型 P27和p21单独及联合作用的影响。这个 这些小鼠对乳腺和皮肤肿瘤的易感性， 无论是自发的还是在接触致癌物后，都将是 下定决心。该项目涉及从基础到基础的科学家的合作 哈钦森中心科学和公共卫生部 加州大学血液学和生物化学系的科学家 华盛顿。费罗博士将通过以下方式进一步加强他的基础科学背景 将分子遗传学和生物统计学课程结合到他的研究中 程序。他的目标是开发转基因动物模型，帮助 揭开细胞周期调控的奥秘，将有助于 开发新型癌症治疗药物。

DESCRIPTION (Applicant's Description): P27 and p21 are two recently discovered proteins which cause a G1 block to cell cycle progression in response to antimitogenic stimuli. Elimination of cell cycle checkpoints mediated by molecules such as these may contribute to cellular transformation or tumor progression. Dr. Fero, an oncologist who completed his medical training at the University of Washington and the Fred Hutchinson Cancer Research Center, has created transgenic mice in order to test these hypotheses. These mice will be studied to assess the overall phenotypic effect of p27 and p21 disruption alone and in combination. The susceptibility of these mice to the development of mammary and skin tumors, both spontaneously and following exposure to carcinogens, will then be determined. The project involves collaboration of scientists from the Basic Sciences and Public Health divisions of the Hutchinson Center with scientists at the Hematology and Biochemistry divisions of the University of Washington. Dr. Fero will enhance his basic science background further by combining molecular genetics and biostatistics coursework to his research program. His goals are to develop transgenic animal models which help to unravel the mysteries of cell cycle regulation and will contribute to the development of new classes of cancer therapeutic agents.