PROSPECTIVE STUDY OF OSTEOPOROSIS & RISK FACTORS IN JRA

骨质疏松症的前瞻性研究

• 批准号: 2429557
• 负责人: Consuelo Diana E RABINOVICH
• 金额: $ 7.56万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2429557
• 关键词: adolescence (12-20); biomarker; bone density; bone fracture; bone metabolism disorder; clinical chemistry; clinical research; disease /disorder prevention /control; disease /disorder proneness /risk; human subject; juvenile rheumatoid arthritis; longitudinal human study; medical complication; middle childhood (6-11); osteopenia; osteoporosis; pathologic bone resorption; pathologic process; photon absorptiometry; preschool child (1-5); radioimmunoassay; statistics /biometry; urinalysis

The long-term goal of this proposal is to reduce the risk for osteopenia and fracture in patients with juvenile rheumatoid arthritis (JRA). The first steps toward this goal are to characterize the natural history of bone disease in JRA and identify, those risk factors which predict reduced bone mass. Strategies for intervention in the prevention and treatment of osteopenia will be derived from the course of skeletal development obtained through sequential measurements of bone mineral density (BMD). The specific aims of this proposal are; (1) to determine whether patients with JRA have a decreased rate of skeletal growth and development by comparing rates of change in BMD to a control group of children; (2) to identify the factors that contribute to abnormalities in bone density and metabolism in the JRA patient population; (3) to characterize bone formation and resorption dynamics through sequential measurement of bone biochemical markers of osteoblastic and osteoclastic activities. The change in BMD in JRA patients versus controls will be compared by performance of analysis of covariance. The impact of putative risk factors on BMD will be evaluated by univariate analysis and by construction of a multivariable model. The primary sponsor for this proposal, Dr. Murray J. Favus, is an accomplished researcher in the field of bone metabolism and bone diseases. Dr. Favus will guide Dr. Rabinovich in the investigation of bone disorders and risk factors for osteoporosis in patients with JRA. Dr. Karrison, the secondary sponsor, is a biostatistician with extensive experience in clinical studies via his research and his work with the Institutional Review Board and the Clinical Research Center (CRC) at the University of Chicago. Dr. Karrison will guide Dr. Rabinovich as she extends her expertise in the field of data analysis. Under the tutelage of Drs. Favus and karrison, Dr. Rabinovich will strive to become a successful independent clinical investigator in the fields of pediatric rheumatology and bone disorders. Dr. Rabinovich has outlined a plan for formal didactic teaching including enrollment in a course sponsored by the CRC entitled "Essentials of Clinical Research", through participation in the Robert Woods Johnson Clinical Scholars Program and by enrollment in a biostatistics course taught by Dr. Karrison. This coursework will augment Dr. Rabinovich's knowledge in health services research, medical ethics, research design, biostatistics and outcome studies. In addition, Dr. Rabinovich will attend weekly interactive seminars at the U of C entitled "Seminars in Health Studies" and remain an active participant in a series of meetings with the Bone Working Group. Dr. Rabinovich's background and experience summarized in the biographical sketch support her participation in the Mentored Clinical Scientist Development program. Dr. Rabinovich has unique abilities, including formal training in epidemiology through the pursuit of a Master's in Public Health in epidemiology. She is board certified in a pediatric rheumatology, a well rounded clinician and teacher. She is developing expertise in the field of bone disorders. Her long term career plans are to pursue a career in academic medicine encompassing clinical research, teaching, and patient care. The Mentored Clinical Scientist Development Award will aid Dr. Rabinovich as she strives to develop into an independent investigator.

该提案的长期目标是降低骨质减少的风险 幼年类风湿性关节炎（JRA）患者的骨折。 这 实现这一目标的第一步是描述自然历史的特征 JRA 中的骨病并确定那些预测减少的危险因素 骨量。 预防和治疗的干预策略 骨质减少会从骨骼发育过程中获得 通过连续测量骨矿物质密度（BMD）。 这 该提案的具体目标是： (1)判断患者是否 患有 JRA 的骨骼生长和发育速度会降低 将 BMD 变化率与对照组儿童进行比较； (2) 至 确定导致骨密度异常的因素， JRA 患者群体的新陈代谢； (3) 骨骼特征 通过连续测量骨的形成和吸收动力学 成骨细胞和破骨细胞活性的生化标志物。 这 JRA 患者与对照组 BMD 的变化将通过以下方式进行比较 协方差分析的性能。 假定风险因素的影响 BMD 将通过单变量分析和构建 多变量模型。 该提案的主要发起人 Murray J. Favus 博士是一位 骨代谢和骨疾病领域颇有成就的研究员。 Favus 博士将指导 Rabinovich 博士进行骨骼疾病的研究 JRA 患者骨质疏松的危险因素。 卡里森博士 第二发起人是一位在以下方面拥有丰富经验的生物统计学家 通过他的研究和与机构的合作进行临床研究 大学审查委员会和临床研究中心 (CRC) 芝加哥。 卡里森博士将指导拉比诺维奇博士扩展她的治疗范围 数据分析领域的专业知识。 在博士的指导下。法乌斯 和卡里森一样，拉宾诺维奇博士将努力成为一名成功的独立人士 小儿风湿病学和骨科领域的临床研究员 失调。 拉比诺维奇博士概述了正式教学计划 包括报名参加由 CRC 赞助的名为“Essentials”的课程 临床研究”，通过参与罗伯特·伍兹·约翰逊 临床学者计划和生物统计学课程的注册 由卡里森博士教授。 本课程将增强 Rabinovich 博士的 卫生服务研究、医学伦理学、研究设计方面的知识， 生物统计学和结果研究。 此外，Rabinovich博士将出席 每周在加州大学举办题为“健康研讨会”的互动研讨会 研究”，并积极参加一系列会议 骨骼工作组。 传记中总结了拉比诺维奇博士的背景和经历 草图支持她参与指导临床科学家 开发计划。 Rabinovich 博士拥有独特的能力，包括正式的 通过攻读公共卫生硕士学位进行流行病学培训 在流行病学中。 她获得了儿科风湿病学委员会的认证， 全面发展的临床医生和教师。 她正在发展以下领域的专业知识 骨疾病领域。 她的长期职业规划是追求事业 学术医学领域，包括临床研究、教学和患者 关心。 指导临床科学家发展奖将帮助博士。 拉宾诺维奇努力发展成为一名独立调查员。