Functional role of a novel DNA modification in the adult brain

成人大脑中新型 DNA 修饰的功能作用

• 批准号: DE190101078
• 负责人: Dr Xiang Li
• 金额: $ 14.4万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2020-08-14
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE190101078
• 关键词: Functional; role; novel; DNA; modification

This project aims to understand how neuronal DNA is modified upon learning and how this impacts memory formation. The project will investigate the combination of different genome-wide sequencing approaches and molecular and cell biological assays to provide new insight into the functional role of a novel DNA modification, N6-methyl-2'-deoxyadenosine in the adult brain. This projects expects to have a major impact on many fields, including neuroscience, evolutionary biology, and genetics, by helping to shape a new way of thinking about gene-environment interactions

该项目旨在了解神经元DNA如何在学习时被修改，以及这如何影响记忆的形成。该项目将研究不同的全基因组测序方法与分子和细胞生物学测定的结合，以提供新的见解，一种新的DNA修饰，N6-甲基-2 '-脱氧腺苷在成人大脑中的功能作用。该项目预计将对许多领域产生重大影响，包括神经科学，进化生物学和遗传学，通过帮助塑造一种新的思维方式来思考基因-环境相互作用