The development of simple, rapid and cost effective test kits and their integration with smartphone technology for monitoring occupational and environmental exposure to the isocyanates – a group of common occupational chemicals and environmental pollutant

开发简单、快速且具有成本效益的测试套件，并将其与智能手机技术集成，用于监测异氰酸酯（一组常见的职业化学品和环境污染物）的职业和环境暴露情况

• 批准号: 700433
• 金额: $ 2.47万
• 依托单位: BIOMARK LIMTED
• 依托单位国家: 英国
• 项目类别: GRD Proof of Market
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=700433
• 关键词: development; simple; rapid; cost; effective

Isocyanates are widespread chemicals with known adverse health effects. Isocyanates areemployed in commercial and consumer applications. The main effects of isocyanate exposureare occupational asthma and lung disease. Some isocyanates are carcinogenic.Studies in the construction industry show up to 57% of spray foam workers demonstrate theeffects of isocyanate exposure. Environmental exposure has been detected in residents livingclose to manufacturers employing isocyanates. Case studies associate families displayingsymptoms of isocyanate exposure with home insulation. Other studies have shown thepresence of isocyanates in medical devices and the exposure of neonatal infants toisocyanates. There is a need for simple, rapid and cost-effective tests for monitoring humanexposure.Exposure to isocyanates can be determined by the rapidly growing discipline of biomonitoring– the measurement of the chemical or a metabolite (biomarker) in the body (e.g. blood andurine) of an exposed individual. However, the best, currently available biomonitoringmethods, require a complicated work-up prior to analysis, are restricted to larger laboratorieswith sophisticated analytical equipment, need skilled technical operators, are not routinelyavailable, provide slow turnaround times and are expensive.Antibody technology allows the development of simple, rapid and cost-effectiveimmunoassays. The production of antibodies to isocyanate biomarkers will enable Biomark todevelop new isocyanate biomonitoring tests. Immunoassays provided in ELISA format willallow the laboratory analysis of large sample numbers and the provision of routine testservices. The development of point of care tests will enable on-site use and real timemonitoring. Integration with smartphone technology will allow data capture, data handlingand test support. Providing employers with immediate confirmation of good working practiceand on the job reassurance to those involved in hazardous tasks.

异氰酸酯是一种广泛存在的化学物质，已知对健康有不良影响。异氰酸酯用于商业和消费应用。异氰酸酯中毒的主要影响是职业性哮喘和肺病。一些异氰酸酯是致癌的。在建筑行业的研究表明，高达57%的喷涂泡沫工人表现出异氰酸酯暴露的影响。在居住在使用异氰酸酯的制造商附近的居民中发现了环境暴露。案例研究将显示异氰酸酯暴露症状的家庭与家庭绝缘联系起来。其他研究表明，医疗器械中存在异氰酸酯，新生儿暴露于异氰酸酯。需要一种简单、快速和具有成本效益的检测方法来监测人类接触异氰酸酯的情况。异氰酸酯的接触情况可以通过迅速发展的生物监测学科来确定--生物监测是测量接触者体内（如血液和尿液）的化学物质或代谢物（生物标志物）。然而，目前最好的生物监测方法在分析前需要进行复杂的后处理，仅限于具有复杂分析设备的大型实验室，需要熟练的技术操作员，不容易获得，周转时间慢且昂贵。抗体技术允许开发简单，快速和具有成本效益的免疫测定。异氰酸酯生物标志物抗体的生产将使Biomark能够开发新的异氰酸酯生物监测测试。以ELISA形式提供的免疫测定将允许对大量样品进行实验室分析并提供常规检测服务。床旁检测的发展将使现场使用和真实的时间监测成为可能。与智能手机技术的集成将允许数据捕获，数据处理和测试支持。为雇主提供良好工作实践的即时确认，并为参与危险任务的人员提供工作保证。