CORE--NEUROIMAGING

B.在MHCRC中的作用和具体目标--假设 大脑中的结构和新陈代谢因素在 精神障碍的发病机制、病程和转归包括 精神分裂症、分裂情感障碍、躁郁症和重度 有精神病症状的抑郁障碍和重度抑郁 精神错乱。神经成像方法可以用来检验这一假说。 此外，磁共振方法也可作为治疗手段。 效果(包括治疗和不良反应)，因此可能对新的 在药物发现方面，以及在疗效和毒性评估方面。这个 神经成像核心的总体目标是：1.提供MHCRC 研究人员使用最先进的核磁共振成像方法进行神经成像， 磁共振波谱和功能磁共振成像是有效和可靠的研究 选定的精神障碍。2.提供技术援助和 与MHCRC调查人员进行科学合作，开发 神经成像方案、数据分析和解释。3.至 开发和实施MRI、MRS和fMRI的新方法 推动神经成像领域的发展，并使这些技术可用于 MHCRC调查人员。4.提供科学的环境， 鼓励将神经成像方法应用于脑梗塞的研究 选定的精神和行为障碍，并提供 用于神经影像研究培训的基础设施。主要目标是 MHCRC的神经成像核心将调查 精神障碍的神经生物学，评估治疗效果，以及 检验MHCRC调查人员的特定假设。这涉及到交叉- 选定患者样本和匹配对照的横断面比较 分组、纵向重复测量选定患者和对照 样本，在磁共振应用的情况下对患者的评估 以前开发和验证的范例(认知、行为 和药理学)以及治疗前后的评估。

B. Role in the MHCRC and Specific Aims - It is hypothesized that structural and metabolic factors in the brain play an important role in the pathogenesis, course and outcome of psychotic disorders including schizophrenia, schizoaffective disorders, manic depressive and major depressive disorders with psychotic symptoms, and major depressive disorders. Neuroimaging methods can be used to test this hypothesis. Moreover, MR approaches can be used as measures of treatment effect (both therapeutic and adverse), and thus may be useful in new drug discovery, as well as in the evaluation of efficacy and toxicity. The overall goals of the Neuroimaging Core are: 1. To provide MHCRC investigators state-of-the-art methods for neuroimaging using MRI, MRS and fMRI that are validated and reliable for the study of selected mental disorders. 2. To provide technical assistance and scientific collaboration to MHCRC investigators in the development of neuroimaging protocols, data analysis, and interpretation. 3. To develop and implement new methods in MRI, MRS and fMRI that advance the field of neuroimaging and make these available to MHCRC investigators. 4. To provide a scientific environment that encourages the application of neuroimaging methods to the study of selected mental and behavioral disorders and provides an infrastructure for training in neuroimaging research. The primary aims of the Neuroimaging Core of the MHCRC are to investigate the neurobiology of mental disorders, assess the effects of treatment, and test specific hypotheses of MHCRC investigators. This involves cross- sectional comparisons of selected patient samples and matched control groups, longitudinal repeated measures of selected patients and control samples, assessment of patients with MR applications in the context of previously developed and validated paradigms (cognitive, behavioral and pharmacologic) and pre and post treatment assessments.