CORE--NEUROIMAGING

核心--神经影像学

• 批准号: 6242935
• 负责人: HAL Cecil CHARLES
• 金额: $ 21.58万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6242935
• 关键词: behavior disorders; biomedical facility; brain metabolism; computer data analysis; diagnosis quality /standard; functional magnetic resonance imaging; image processing; magnetic resonance imaging; mental disorder diagnosis; mental disorders; method development; neurosciences; nuclear magnetic resonance spectroscopy

B. Role in the MHCRC and Specific Aims - It is hypothesized that structural and metabolic factors in the brain play an important role in the pathogenesis, course and outcome of psychotic disorders including schizophrenia, schizoaffective disorders, manic depressive and major depressive disorders with psychotic symptoms, and major depressive disorders. Neuroimaging methods can be used to test this hypothesis. Moreover, MR approaches can be used as measures of treatment effect (both therapeutic and adverse), and thus may be useful in new drug discovery, as well as in the evaluation of efficacy and toxicity. The overall goals of the Neuroimaging Core are: 1. To provide MHCRC investigators state-of-the-art methods for neuroimaging using MRI, MRS and fMRI that are validated and reliable for the study of selected mental disorders. 2. To provide technical assistance and scientific collaboration to MHCRC investigators in the development of neuroimaging protocols, data analysis, and interpretation. 3. To develop and implement new methods in MRI, MRS and fMRI that advance the field of neuroimaging and make these available to MHCRC investigators. 4. To provide a scientific environment that encourages the application of neuroimaging methods to the study of selected mental and behavioral disorders and provides an infrastructure for training in neuroimaging research. The primary aims of the Neuroimaging Core of the MHCRC are to investigate the neurobiology of mental disorders, assess the effects of treatment, and test specific hypotheses of MHCRC investigators. This involves cross- sectional comparisons of selected patient samples and matched control groups, longitudinal repeated measures of selected patients and control samples, assessment of patients with MR applications in the context of previously developed and validated paradigms (cognitive, behavioral and pharmacologic) and pre and post treatment assessments.

B。 在MHCRC中的作用和具体目标-假设 大脑中的结构和代谢因素在 精神障碍的发病机制、病程和结局，包括 精神分裂症、情感障碍、躁狂抑郁症和重 伴有精神病症状的抑郁症，以及重度抑郁症 紊乱 神经影像学方法可以用来检验这一假设。 此外，MR方法可用作治疗措施 效果（治疗和不良），因此可能有助于新的 药物发现，以及疗效和毒性的评估。的 神经影像学核心的总体目标是：1。 提供MHCRC 研究人员使用MRI进行神经成像的最先进方法， MRS和fMRI是有效的和可靠的研究， 选择性精神障碍 2. 提供技术援助和 科学合作，以MHCRC研究人员在发展 神经成像方案、数据分析和解释。 3. 到 开发和实施MRI、MRS和fMRI的新方法， 推进神经影像学领域的发展， MHCRC调查员。4. 提供一个科学的环境， 鼓励将神经影像学方法应用于研究 选择精神和行为障碍，并提供一个 神经影像学研究培训的基础设施。 主要目标 MHCRC的神经影像核心是调查 精神障碍的神经生物学，评估治疗效果，以及 测试MHCRC调查人员的具体假设。 这涉及到跨- 选定患者样本和匹配对照的截面比较 组，选定患者和对照组的纵向重复测量 样本，在以下背景下对MR应用患者进行评估 先前开发和验证的范例（认知、行为 和药理学）以及治疗前和治疗后评估。