CORE--NEUROIMAGING

核心--神经影像学

• 批准号: 6111294
• 负责人: HAL Cecil CHARLES
• 金额: --
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-16 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6111294
• 关键词: behavior disorders; biomedical facility; brain metabolism; computer data analysis; diagnosis quality /standard; functional magnetic resonance imaging; image processing; magnetic resonance imaging; mental disorder diagnosis; mental disorders; method development; neurosciences; nuclear magnetic resonance spectroscopy

B. Role in the MHCRC and Specific Aims - It is hypothesized that structural and metabolic factors in the brain play an important role in the pathogenesis, course and outcome of psychotic disorders including schizophrenia, schizoaffective disorders, manic depressive and major depressive disorders with psychotic symptoms, and major depressive disorders. Neuroimaging methods can be used to test this hypothesis. Moreover, MR approaches can be used as measures of treatment effect (both therapeutic and adverse), and thus may be useful in new drug discovery, as well as in the evaluation of efficacy and toxicity. The overall goals of the Neuroimaging Core are: 1. To provide MHCRC investigators state-of-the-art methods for neuroimaging using MRI, MRS and fMRI that are validated and reliable for the study of selected mental disorders. 2. To provide technical assistance and scientific collaboration to MHCRC investigators in the development of neuroimaging protocols, data analysis, and interpretation. 3. To develop and implement new methods in MRI, MRS and fMRI that advance the field of neuroimaging and make these available to MHCRC investigators. 4. To provide a scientific environment that encourages the application of neuroimaging methods to the study of selected mental and behavioral disorders and provides an infrastructure for training in neuroimaging research. The primary aims of the Neuroimaging Core of the MHCRC are to investigate the neurobiology of mental disorders, assess the effects of treatment, and test specific hypotheses of MHCRC investigators. This involves cross- sectional comparisons of selected patient samples and matched control groups, longitudinal repeated measures of selected patients and control samples, assessment of patients with MR applications in the context of previously developed and validated paradigms (cognitive, behavioral and pharmacologic) and pre and post treatment assessments.

B.在MHCRC中的作用和特定目的-假设