CENTER FOR RESEARCH ON FERTILITY AND INFERTILITY

这个P30中心核心补助金更新申请是一个直接的产物， 过去15年来发展的研究需求， 美国西北大学的研究人员， 生育和不育领域的研究。 十四 研究人员目前持有25个NIH研究资助/项目 将进入四个科学核心 其中16个 赠款/项目通过国家排雷中心供资。 研究计划将 由P30中心核心补助金提供服务的包括对 生殖的神经内分泌学，性腺的调节机制， 功能，配子发生的调节机制， 卵泡选择，生殖激素的作用机制， 参与生殖的基因的转录调控， 调节生殖道功能的机制和免疫学 调节生育力的机制。 拟建P30中心的研究者 核心赠款目前正在解决生殖科学方面的问题 在生物化学、分子、细胞、生理和行为方面 程度. 生殖领域生命科学的复杂性 今天的研究需要分享技术和方法， 通常在单个研究实验室中无法获得。 事实上， 我们对生殖系统理解的重大突破 这将需要具有专业知识的研究人员的合作努力， 不同的研究领域。 因此，该补助金旨在维持三个 建立核心（蛋白质分析，原位杂交/分子生物学 技术，以及激素和神经递质测量核心），并 创建一个新的核心（重组蛋白核心）， 调查人员将高度复杂的技术融入他们的 以具有成本效益的方式进行研究。 此外，核心将 提供质量控制和技术专长，在一些不同的 个人通常无法获得的水平上的方法 investigators. 还将继续建立一个行政核心， 管理中心补助金。 P30中心核心的建立 四年前的格兰特对质量、数量和 现有的联邦资助的研究计划的成本效益， 西北大学的生殖科学 它还促进了 P30中心成员之间的广泛合作以及 P30研究人员和其他科学家之间的关系，无论是在内部还是外部， 西北大学 更新中包括的已建立的和新的核心 P30核心中心赠款之所以被选中，是因为它们具有很高的影响力， 在西北大学的生殖研究中， 旨在更好地了解监管机制， 潜在的生育能力和不育能力。

This P30 Center Core Grant renewal application is a direct outgrowth of the research needs that have developed over the past 15 years by investigators at Northwestern University who are engaged in reproductive research in the areas of fertility and infertility. Fourteen investigators currently holding 25 funded NIH research grants/projects will access the four proposed scientific cores. Sixteen of these grants/projects are funded through the NICHD. The research programs to be served by the P30 Center Core Grant include investigations into the neuroendocrinology of reproduction, the regulatory mechanisms of gonadal functions, the regulatory mechanisms of gametogenesis, the mechanisms of follicular selection, the mechanisms of action of reproductive hormones, the transcriptional regulation of genes involved in reproduction, the mechanisms regulating genital track functions and the immunological mechanisms regulating fertility. Investigators in the proposed P30 Center Core Grant are currently addressing questions in the reproductive sciences at the biochemical, molecular, cellular, physiological and behavioral levels. The complexity of the life sciences in the area of reproductive research today requires the sharing of techniques and approaches that are often not available in a single research laboratory. Indeed, it is clear that major breakthroughs in our understanding of the reproductive system will require collaborative efforts of researchers who have expertise in diverse areas of research. Thus, this grant seeks to maintain three established cores (Protein Analysis, In Situ Hybridization/Molecular Technology, and Hormone and Neurotransmitter Measurement Cores), and to create one new core (Recombinant Protein Core) which will enable Core investigators to incorporate highly sophisticated techniques into their research programs in a cost-effective manner. Furthermore, the Cores will provide quality control and technical expertise in a number of different methodologies at a level normally not available to individual investigators. An Administrative Core will also be continued to administer the Center Grant. The establishment of this P30 Center Core Grant four years ago has had a major impact on the quality, quantity and cost-effectiveness of existing federally-funded research programs in the reproductive sciences at Northwestern University. It has also fostered extensive collaborations between members of the P30 Center as well as between P30 investigators and other scientists both within and outside of Northwestern. The established and new cores included in the renewal of the P30 Core Center Grant were selected because of the high impact they can be expected to have on reproductive research at Northwestern that is aimed at developing a better understanding of the regulatory mechanisms underlying fertility and infertility.