Market research to validate the commercial potential for a novel cloud-based application to enable medicinal chemists to rationally design new compounds for pharmaceutical R&D.

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Outsourcing of chemical synthesis is the backbone of the modern paradigm forpharmaceutical R&D, particularly in the early discovery phase of a project. This has meant aradical change in terms of the composition of Pharma R&D teams, where in the past therewould have been a large team of chemists supporting each project, there is now one or twosenior chemists who function as molecule designers, who are backed up by remote teams(often in India, China or other low-cost locations) responsible for the synthesis of the designedmolecules. Cresset have an existing suite of software tools aimed at helping bothcomputational and medicinal chemists with the design and synthesis of molecules, particularlyhelping with the understanding of the 3D properties of the molecules and their interactionswith target proteins; however it is our belief that with the new paradigm there is an increasingneed for new tools to facilitate project communication and speed up the delivery of newmolecules. We intend to carry out market research in this area to validate our belief that a newsoftware application, based on a cloud platform and delivering 3D design capability, plus 2Dstructural entry and representation, will meet the needs of the senior scientists designing themolecules, the outsource synthesis teams making the molecules, and the other members of theproject team who rely on getting access to the structures and related information in an easyand timely manner. We intend to further validate the market opportunity for both a securepublic cloud application and an internally hosted private cloud application, which wouldappeal more to large Pharma customers (the former appealing to academics and smallercompanies). We believe there is a significant worldwide market opportunity for such a tool,but we strongly need to validate our concept with broader market data than we have been ableto access from our current customer contacts.