Global positioning system for small molecules: accelerating lead discovery

小分子全球定位系统：加速先导化合物发现

• 批准号: DE190100015
• 负责人: A/Prof Christoph Nitsche
• 金额: $ 28.44万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-03-01 至 2022-06-12
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE190100015
• 关键词: Global; positioning; system; small; molecules

This project aims to establish a tool to accelerate lead generation from very small molecules. This will shift the paradigm in the identification of small molecules that can serve as lead compounds for the development of specific probes or drugs. This project offers a new strategy to rapidly generate lead compounds from a library of compound fragments. The new approach is expected to facilitate identification and development of new lead molecules, drawing on advances made in the field of fragment-based lead discovery, which is increasingly used in the pharmaceutical industries. The tools developed can also be applied for imaging of biological processes. By developing new technologies, the project should deliver intellectual property with potential for commercialisation.

该项目旨在建立一种工具，以加速从非常小的分子中产生铅。这将改变识别小分子的模式，这些小分子可以作为开发特定探针或药物的先导化合物。该项目提供了一种从化合物片段库快速生成先导化合物的新策略。新的方法预计将有助于识别和开发新的铅分子，利用在基于片段的铅发现领域取得的进展，这在制药行业中越来越多地使用。开发的工具也可以应用于生物过程的成像。通过开发新技术，该项目应提供具有商业化潜力的知识产权。