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AGGRESSIVE BEHAVIOR AND ANDROGEN SURGES

攻击性行为和雄激素激增

基本信息

批准号：
2519691
负责人：
STEVEN M PHELPS
金额：
$ 1.45万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-09-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/2519691
关键词：
aggression androgen receptor behavioral /social science research tag hormone regulation /control mechanism testosterone violence

项目摘要

Any attempt to gain insight into the biological substrates of violence, which the National Center for Disease Control has labeled the most prominent health concern afflicting Americans, ought to address interactions of environmental and biological determinants, and do so in a way that suggests the generality of these mechanisms. Transient testosterone (T) surges that follow successful aggression are hypothesized to act as positive reinforcers and as rapid activators of aggression through actions on membrane steroid receptors. Exogenously administered T-surges, successful aggression in intact animals, and successful aggression in castrates with tonic-release T-implants will be tested for reinforcement properties in an operant conditioning paradigm. Measurement of aggressive responsiveness to intruding males shortly after administration of exogenous T-surges will be used to test rapid activating effects of T. Membrane binding sites for T and its metabolites, estradiol and 5 alpha-dihydrotestosterone, will be sought and characterized using conjugates of the steroids to bovine serum albumin and quantitative autoradiography of cryostat sections of the forebrain. If regions of high expression are found and binding sites have the characteristics of receptors, the cDNA corresponding to those sites will be cloned. Cloning will employ insertion into a plasmid vector, expression in eukaryotic host cells, and several rounds of expression screening and retransfection, before isolating and sequencing insert DNA. Understanding mechanisms of aggression in the study organism, Anolis carolinensis, will facilitate future comparative study using a subgroup of its over 250 congeners.

任何试图深入了解暴力的生物学基础的尝试，美国国家疾病控制中心称之为困扰美国人的突出健康问题，应该解决环境和生物决定因素的相互作用，并在一种暗示这些机制的普遍性的方式。瞬态成功攻击后睾丸激素（T）激增，假设作为积极的免疫和快速激活剂，通过对膜类固醇受体的作用进行攻击。外源给予T波，在完整动物中成功攻击，成功的侵略阉割与强直释放T型植入物将在操作性条件反射范例中测试强化特性。测量入侵后不久的攻击性反应外源性T峰的施用将用于测试快速 T. T及其受体的膜结合位点将寻找代谢产物雌二醇和5 α-双氢睾酮并使用类固醇与牛血清的缀合物进行表征白蛋白和定量放射自显影的冷冻切片的前脑如果发现高表达的区域并且结合位点具有受体的特征，对应于这些位点的cDNA 将被克隆。克隆将采用插入质粒载体，在真核宿主细胞中的表达，以及几轮表达筛选和再转染，然后分离和测序插入DNA。了解研究生物体中的攻击机制，Anolis carolinensis，将促进未来的比较研究，使用亚组超过250种同类物。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neural networks predict response biases of female túngara frogs.

神经网络预测雌性通加拉青蛙的反应偏差。

DOI：
10.1098/rspb.1998.0293
发表时间：
1998
期刊：
Proceedings. Biological sciences
影响因子：
0
作者：
Phelps,SM;Ryan,MJ
通讯作者：
Ryan,MJ

Vestigial preference functions in neural networks and túngara frogs.

神经网络和通加拉青蛙中的残留偏好函数。

DOI：
10.1073/pnas.231296998
发表时间：
2001
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Phelps,SM;Ryan,MJ;Rand,AS
通讯作者：
Rand,AS

History influences signal recognition: neural network models of túngara frogs.

历史影响信号识别：通加拉青蛙的神经网络模型。