CARDIOVASCULAR & PAIN TOLERANCE RESPONSES IN HEALTHY ADU

心血管

• 批准号: 2460296
• 负责人: EDITH E BRAGDON
• 金额: $ 1.45万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2460296
• 关键词: adult human (21+); behavior test; behavioral /social science research tag; blood pressure; cardiac output; cardiovascular disorder; catecholamines; clinical research; depression; endorphins; heart rate; human subject; myocardial ischemia /hypoxia; pain; psychological stressor; psychophysiology; rest; vascular resistance

The proposed study will examine several issues pertaining to the effect of behavioral stress on cardiovascular and pain regulatory systems and their possible interaction in healthy men and women with depressed mood but without major depression or any chronic pain disorder. Measures of thermal and ischemic pain sensitivity will be assessed at baseline and after a 5- minute stress (stress day) or rest (control day) period. Systolic and diastolic blood pressure, heart rate., impedance-derived estimates of stroke volume, cardiac output, and total peripheral resistance, and beta- endorphin and catecholamine levels will be measured during baseline, rest and stress periods, and accompanying pain measurement. A major goal is to extend my previous findings relating stress-induced analgesia to blood pressure reactivity to stress in normotensive humans. The study's results may have implications for models of psychophysiological mechanisms contributing to the development of cardiovascular disease, and for the experience of anginal pain versus painless (silent) myocardial ischemia in patients with coronary heart disease.

拟议的研究将审查与下列因素的影响有关的几个问题： 行为应激对心血管和疼痛调节系统及其 健康的男性和女性抑郁情绪可能的相互作用， 没有重度抑郁症或任何慢性疼痛障碍 热测量 和缺血性疼痛敏感性将在基线和5- 分钟的压力（压力日）或休息（控制日）期间。 收缩压和 舒张压，心率，阻抗导出估计 每搏输出量、心输出量和总外周阻力，以及β- 内啡肽和儿茶酚胺水平将在基线、休息、 和压力时期，以及伴随的疼痛测量。 一个主要目标是 将我先前的研究结果扩展到血液 血压正常的人对压力的压力反应。 这项研究的结果 可能对心理生理机制的模型 导致心血管疾病的发展， 心绞痛与无痛（无症状）心肌缺血的经验， 冠心病患者。