BASAL GANGLIA AND CEREBELLAR INPUTS TO PREFRONTAL CORTEX

基底神经节和小脑对前额皮质的输入

• 批准号: 2033085
• 负责人: Frank A. Middleton
• 金额: $ 1.45万
• 依托单位: UPSTATE MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2033085
• 关键词: basal ganglia; central neural pathway /tract; cerebellum; motor cortex

The basal ganglia and cerebellum are known to receive inputs from widespread regions of the cerebral cortex, such as the prefrontal, posterior parietal, and temporal lobes. According to one viewpoint, these inputs are integrated in the basal ganglia and cerebellum, and directed to the primary motor cortex, or other cortical motor areas, for use in the control of movement. However, Alexander, Delong, and Strick (1986) and Leiner, Leiner, and Dow (1991, 1993), proposed that significant portions of the output from the basal ganglia and cerebellum target the same regions of the frontal lobe which they receive input from. Thus, according to this scheme, it is possible that several non-motor "loops" exist between the prefrontal cortex and the basal ganglia and cerebellum. Despite the absence of direct anatomical evidence for the existence of such loops, there have been many suggestions about their role in a number of neurological and psychiatric disorders. The proposed experiments are designed to examine the possible existence of the prefrontal loops and the potential role of the basal ganglia and cerebellum in cognitive function. First, it will be determined if the basal ganglia and cerebellum have anatomical connections with regions of the prefrontal cortex that are known to be involved in cognitive function. Second, the degree of separation of these pathways from each other and from previously-described pathways that are involved in motor functions will be determined. To address these issues, retrograde transneuronal transport with the McIntyre-B strain of herpes simplex virus type 1 will be used in cebus monkeys. This technique will enable the direct observation of any pathways in the basal ganglia and cerebellum which are directed to the different prefrontal regions.

已知基底神经节和小脑接受来自 大脑皮层的广泛区域，如前额叶， 后顶叶和颞叶根据一种观点， 输入被整合在基底神经节和小脑中， 至初级运动皮质或其它皮质运动区，用于 运动的控制。然而，亚历山大、德隆和斯特里克（1986年） Leiner，Leiner和Dow（1991，1993）提出， 来自基底神经节和小脑的输出的一部分靶向 大脑额叶的同一区域也是他们接收信息的地方因此，在本发明中， 根据该方案，可以将几个非电动机“回路” 存在于前额叶皮层与基底神经节和小脑之间。 尽管没有直接的解剖学证据证明 关于这种循环，有许多关于它们在许多方面的作用的建议。 神经和精神疾病建议的实验是 旨在检查前额叶回路的可能存在， 基底神经节和小脑在认知中的潜在作用 功能首先，将确定基底神经节和 小脑与前额叶区域有解剖学上的联系 与认知功能有关的大脑皮层。二是 这些途径彼此分离的程度， 先前描述的参与运动功能的通路将 被确定。为了解决这些问题，逆行跨神经元 单纯疱疹病毒1型McIntyre-B株的运输将 用在猕猴身上这项技术将使直接 观察基底神经节和小脑中的任何通路， 指向不同的前额叶区域。

项目成果

New concepts about the organization of basal ganglia output.

关于基底神经节输出组织的新概念。

• 发表时间: 1997
• 期刊: Advances in neurology.
• 作者: Middleton,FA;Strick,PL
• 通讯作者: Strick,PL

Dentate output channels: motor and cognitive components.

齿状输出通道：运动和认知组件。

• DOI: 10.1016/s0079-6123(08)63386-5
• 发表时间: 1997
• 期刊: Progress in brain research
• 作者: Middleton,FA;Strick,PL
• 通讯作者: Strick,PL