NEUROBIOLOGY OF COGNITIVE DEVELOPMENT--LATENT INHIBITION

这项提案旨在研究一种 经典儿童潜伏抑制(LI)的发育性变化 条件眼皮反应。我们实验室以前的数据表明 条件反射在出生后第17天(PND17)和PND24之间逐渐出现 (斯坦顿，弗里曼和斯凯尔顿，1992；弗里曼，斯宾塞，斯凯尔顿和斯坦顿， 1993年)。我们实验室最近对婴儿进行的研究使我们有可能观察到 不仅是眼皮的行为和神经发育 已知依赖小脑的大鼠的条件反射 但要进一步将这一分析扩展到其他大脑结构，如 海马体，以及它们可能在调节高等 订单形式的学习，如(李)，在这个后期发展中 学习系统。为了解决这些问题，对 我已经在我们的实验室开展了工作，开始建立个体发育 这种行为。我们已经证明，虽然20天大的幼崽没有表现出 潜伏性抑制，24日龄和32日龄大鼠有。我们打算表演 选择性内侧间隔损害，然后在LI上测试幼鼠是否 这种行为被打乱了。这一行为的个体发生可能反映了 海马体和小脑之间的发育相互作用。

This proposal is designed to examine the biological bases of a developmental change in latent inhibition (LI) of the classically conditioned eyelid response. Previous data from our lab suggests that conditioning emerges gradually between postnatal day 17 (PND17) and PND24 (Stanton, Freeman, & Skelton, 1992; Freeman, Spencer, Skelton, & Stanton, 1993). Recent work in infants in our lab makes it possible to look at not only the behavioral and the neurological development of eyelid conditioning in the rat which is known to be dependent on the cerebellum but to further extend this analysis to other brain structures, such as the hippocampus, and what their role might be in the modulation of higher order forms of learning, such as (LI), within this late developing learning system. In order to address these issues preliminary studies of LI have been carried out in our lab to begin to establish the ontogeny of this behavior. We have shown that while 20-day-old pups do not show latent inhibition, 24-and 32-day-old rats do. We propose to perform selective medial septal lesions and afterwards test pups on LI to see if this behavior is disrupted. The ontogeny of this behavior may reflect a developmental interaction between the hippocampus and cerebellum.