Process Scale-up using the CPI National Industrial Biotechnology Facility

使用 CPI 国家工业生物技术设施进行工艺放大

• 批准号: 710080
• 金额: $ 7.6万
• 依托单位: CORESSENCE LIMITED
• 依托单位国家: 英国
• 项目类别: GRD Proof of Concept
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=710080
• 关键词: Process; Scale; up; using; CPI

Coressence Ltd developed an advanced phytoneutrient extraction process operating at "sub kg" scale under TSB project J9009 (2006-8) using Critical Processes Ltd as a subcontractor.The process produces a commercial product with a high yield epicatechin monomer (>30% w/w) and flavan-3-ol oligomers from selected apple varieties. Epicatechin is a food, supplement and medical food-based vasodilator while oligomers are effective anti-angiogenic products which are used in skin care and medical foods. Coressence markets these products through a range of direct sale, global licensing and collabrative arrangements. This project will undertake scale-up trials for a "100 kg" scale unit as the first stage in the devlopment and construction of a "1000 kg" process. The project will undertake detailed process up-scaling taking account of the necessary criteria required to meet commercial and industry standards.The project will involve the use equipment recently commissioned as part of the open access UKCPI National Industrial Biotechnology Facility at the Wilton Centre.

Coressence有限公司开发了一种先进的植物营养素提取工艺，在TSB项目J9009(2006-8)下以关键过程有限公司作为分包商进行操作。该工艺从选定的苹果品种中生产出具有高产量的表儿茶素单体(&gt；30%w/w)和黄烷-3-醇低聚物的商业产品。表儿茶素是以食品、补充剂和医用食品为基础的血管扩张剂，齐聚物是有效的抗血管生成产品，用于皮肤护理和医疗食品。Coressence通过一系列直销、全球授权和合作安排来营销这些产品。该项目将进行“100公斤”规模单位的放大试验，作为“1000公斤”工艺开发和建设的第一阶段。该项目将考虑到满足商业和工业标准所需的必要标准，进行详细的流程放大。该项目将涉及最近作为威尔顿中心开放接入UKCPI国家工业生物技术设施的一部分投入使用的设备。