PHYSICAL ACTIVITY AND NIDDM DEVELOPMENT

描述：(改编自《调查者摘要》) 建议继续调查体力活动在 非胰岛素依赖型糖尿病(NIDDM)的进展 皮马印第安人。调查人员指出，这一努力是 独特之处在于，这是为数不多的正在进行的研究之一 人群的体力活动水平和糖耐量测定 对NIDDM的发展具有很高的风险。调查员进一步指出 通过Kriska体力活动问卷收集的数据 在首席调查员第一次获奖期间提供了一个独特的机会 研究体力活动与运动之间的纵向关系 葡萄糖不耐受。 与这一人群的横断面发现相矛盾的是， 初步的纵向分析不支持显著的关系 体力活动与NIDDM的发展之间的关系。这是不是 最初的纵向检查实际上是正确的，或者是 力量不足(男性缺乏病例，缺乏体力活动范围 女性的活动)尚不清楚。调查员继续寻求资金 在更长的后续时间内研究这一问题。第二个目的是 这项建议是为了研究活动在发展 皮马印第安人中NIDDM常见的各种并发症。调查员 声明这一努力很重要，因为目前知之甚少 关于体力活动和血压之间的联系， 视网膜病变、高血压、肾病和心血管疾病 有葡萄糖不耐受的个体。

DESCRIPTION: (Adapted from Investigator's Abstract) The purpose of this proposal is to continue to investigate the role of physical (in)activity in the development of non-insulin dependent diabetes mellitus (NIDDM) in the Pima Indian population. The investigator points out that this effort is unique in that this is one of the only studies with an ongoing collection of both physical activity levels and glucose tolerance measures in a population at high risk for the development of NIDDM. The investigator further notes that the data collected with the Kriska physical activity questionnaire during the Principal Investigator's First Award provide a unique opportunity to investigate the longitudinal relationship between physical activity and glucose intolerance. In contradiction to the cross-sectional findings in this population, preliminary longitudinal analyses do not support a significant relationship between physical activity and the development of NIDDM. Whether this initial longitudinal examination is, in fact, correct or is the result of insufficient power (lack of cases in males and lack of range of physical activity in females) is not clear. The investigator seeks continued funding to examine this issue during a longer follow-up time. A second purpose of this proposal is to examine the role of activity in the development of the various complications common to NIDDM in the Pima Indians. The investigator states that this effort is important since little is currently known regarding the association between physical activity and blood pressure, retinopathy, hypertension, nephropathy, and cardiovascular disease in individuals with glucose intolerance.