THE ROLE OF PHYSICAL ACTIVITY IN NIDDM DEVELOPMENT

糖尿病及其相关并发症是导致糖尿病的主要原因之一， 死亡和残疾在美国。 在糖尿病患者中， 非胰岛素依赖型糖尿病（NIDDM）是最常见的类型， 占所有糖尿病病例的90%以上。 更好地了解 疾病，一项前瞻性研究已经在人群中进行了25年 皮马印第安人，他们拥有最高的记录， NIDDM的发病率。 本提案的目的是 调查身体活动作为潜在风险因素的作用， NIDDM在这一高危人群中的发展。 已经编制了一份活动调查表，供皮马印第安人使用。 研究旨在收集该人群报告的体力活动数据。 利用现有的准确性测试方法， 证明是可行和可靠的。 为此，自 1987年，这份调查问卷已被管理到皮马印第安人， 作为研究诊所数据收集计划的一部分。 这项建议的具体目的是检验物理学的假设， 皮马印第安人的不活动与葡萄糖的恶化有关 耐受性，无论是作为一个独立的风险因素，或通过其关联 肥胖症 这将通过两种不同的方式进行检查：1）评估 报告的身体活动与 血糖和胰岛素水平以及血糖的风险因素 不耐受;和2）前瞻性评价之间的关系 体力活动和随后发生葡萄糖的风险 不耐症和肥胖症。 这项建议将提供必要的监督和人员， 继续收集皮马人的体力活动数据， 考虑到体力活动和NIDDM之间的前瞻性关系 接受检查

Diabetes, with its associated complications, is one of the leading causes of death and disability in the United States. Among those with diabetes, non-insulin-dependent diabetes mellitus (NIDDM) is the most common type, accounting for over 90% of all diabetic cases. To better understand the disease, a prospective study has been underway for 25 years in a population of Native Americans, the Pima Indians, who have the highest documented rates of NIDDM in the world. The purpose of this current proposal is to investigate the role of physical activity as a potential risk factor for the development of NIDDM in this high risk population. An activity questionnaire had been developed for use in the Pima Indian study to collect reported physical activity data in this population. Utilizing available methods of accuracy testing, this questionnaire was demonstrated to be both feasible and reliable. For this reason, since 1987, this questionnaire has been administered to the Pima Indian participants as part of the data collection scheme at the study clinic. The specific aim of this proposal is to test the hypothesis that physical inactivity in the Pima Indians is associated with a worsening of glucose tolerance, either as an independent risk factor, or through its association with obesity. This will be examined in two separate ways: 1) evaluation of the cross-sectional association between reported physical activity and both blood glucose and insulin levels and the risk factors for glucose intolerance; and 2) prospective evaluation of the relationship between physical activity and the subsequent risk of development of glucose intolerance and obesity in this population. This proposal will provide the necessary supervision and personnel for continued collection of physical activity data in the Pima population to allow for the prospective relationship between physical activity and NIDDM to be examined.