GENERAL CLINICAL RESEARCH CENTER

全科临床研究中心

• 批准号: 2039838
• 负责人: HAROLD J FALLON
• 金额: $ 181.94万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2039838
• 关键词: clinical research; human subject

The University of Alabama at Birmingham General Clinical Research Center is a multidisciplinary facility available to faculty members of the Schools of Medicine and Dentistry for the pursuit of clinical investigation. The GCRC and its staff facilitate the meticulous control of experimental conditions, close observation and accurate monitoring of biologic phenomena, and the precise measurement of biochemical and physiological events which occur in patients and normal volunteers participating in research activities. Facilities of the Center increase the efficiency and productivity of research efforts on individually funded projects, afford participants more flexibility in taking new research directions, and promote more collaborative research among a group having multidisciplinary approaches to science. Research projects involve the following investigations: post-transplantation hypertension, disorders of the immune system, renal diseases, multiple sclerosis, herpesvirus infections, AIDS, cytomegalovirus infection, anaplastic gliomas, left ventricular dysfunction, cardiac arrhythmia, histoplasmosis, metastatic melanoma, aspergillus, monoclonal antibody in advanced colorectal carcinoma, advanced ovarian carcinoma, cisplatin toxicities, fat malabsorption in AIDS and ARC patients, gastroesophageal reflux, candidemia, condylomata acuminata, extrarenal potassium disposal in sickle cell anemia, atrial natriuretic peptide in chronic hypoxic pulmonary hypertension, epinephrine sensitivity in hypokalemic periodic paralysis, antifolate therapy of autoimmune diseases, dopamine antagonism on craving and loss of control in alcoholics, role of saliva in determining the alkaline environment of the esophagus, chimeric anti-CD4 in rheumatoid arthritis, epinephrine on extrarenal potassium disposal in end-stage renal disease, renal dysfunction in cyclosporin-treated kidney transplant patients, extrarenal potassium disposal in diabetic dialysis patients, glycine therapy for 3-methyl crotonyl COA carboxylase deficiency, asymptomatic cardiac ischemia, atherosclerotic heart disease, growth factor expression and production in lungs in progressive systemic disease.

亚拉巴马大学伯明翰综合临床研究中心 是一个多学科的设施提供给教师的 医学和牙科学院，以追求临床 调查 GCRC及其工作人员负责对 实验条件，密切观察和准确监测， 生物现象，以及生物化学和 发生在患者和正常志愿者中的生理事件 参与研究活动。 中心设施增加 个人研究工作的效率和生产力 资助项目，让参加者更灵活地采取新的 研究方向，并促进更多的合作研究之间， 对科学采取多学科方法的团体。 研究项目 涉及以下研究：移植后高血压， 免疫系统疾病、肾脏疾病、多发性硬化症、 疱疹病毒感染，艾滋病，巨细胞病毒感染，间变性 神经胶质瘤，左心室功能障碍，心律失常， 组织胞浆菌病，转移性黑色素瘤，曲霉菌，单克隆抗体 晚期结直肠癌，晚期卵巢癌，顺铂 毒性，AIDS和ARC患者的脂肪吸收不良，胃食管 反流，念珠菌血症，尖锐湿疣，肾外排钾 在镰状细胞性贫血中，慢性缺氧 肺动脉高压，肾上腺素敏感性 瘫痪，自身免疫性疾病抗叶酸治疗，多巴胺拮抗作用 关于酗酒者的渴望和失控，唾液在 确定食管的碱性环境，嵌合抗CD 4 在类风湿性关节炎中，肾上腺素对肾外钾的处置 终末期肾病，环孢素治疗肾功能不全 移植患者，糖尿病透析肾外钾处置 3-甲基巴豆酰辅酶A羧化酶的甘氨酸治疗 缺乏症、无症状性心肌缺血、动脉粥样硬化性心脏病， 进行性系统性肺损伤肺组织中生长因子的表达和产生 疾病