MEMORY AND EMOTION IN PTSD PATIENTS AND CONTROLS

PTSD 患者的记忆和情绪及其控制

• 批准号: 2521306
• 负责人: AMY S GARRETT
• 金额: $ 2.43万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-26 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2521306
• 关键词: amygdala; behavioral /social science research tag; brain electrical activity; brain mapping; cingulate gyrus; clinical research; emotions; functional magnetic resonance imaging; hippocampus; human subject; memory; neurosciences; posttraumatic stress disorder

Several behavioral studies have shown that memory is often enhanced for emotional stimuli in normals. Compared to normals, patients with Post-Traumatic Stress Disorder (PTSD) exhibit selectively enhanced recall for trauma-related material. but show deficits in recall of neutral stimuli. This suggests a functional abnormality of the emotional memory system in PTSD. Previous neuroimaging and neurobioligical studies have suggested that the amygdala, hippocampus, posterior cingulate, retrosplenial cortex, and prefrontal cortex are involved in the acquisition and retrieval of emotional episodic memory. This study uses fMRI to investigate neurofunctional differences between patients with PTSD and controls during the presentation of emotional and neutral stimuli. Subsequent recall and recognition of the stimuli will describe individual and group differences in memory performance. We hypothesize that PTSD subjects, compared to controls, will show increased amygdala and posterior cingulate cortex activation in response to threatening stimuli, but decreased hippocampus activation in response to neutral stimuli. Also, performance on the recall task will be related to the degree of activation in the amygdala and hippocampus. These studies will contribute to the understanding of how the brain enhances memory of emotional stimuli and how this memory for emotional and neutral stimuli may be altered in PTSD. These data will provide the foundation for a systematic program of clinical neuroscience research in PTSD.

一些行为研究表明，记忆通常会增强 正常的情绪刺激。 与正常人相比 创伤后应激障碍（PTSD）有选择地增强 召回与创伤相关的材料。 但是在召回中显示不足 中性刺激。 这表明该功能异常 PTSD中的情绪记忆系统。 以前的神经影像学和 神经生物学研究表明，杏仁核，海马， 后扣带回，脾后皮质和前额叶皮层为 参与了情感情节记忆的获取和检索。 这项研究使用fMRI研究 在表现情绪和对照的患者情绪和对照的患者中 中性刺激。 随后对刺激的召回和认可将 描述内存性能的个人和群体差异。 我们 假设与对照组相比，PTSD受试者将显示 杏仁核和后扣带回皮层激活增加的响应 威胁刺激，但响应降低了海马激活 进行中性刺激。 另外，召回任务的表现将是 与杏仁核和海马的激活程度有关。 这些研究将有助于理解大脑 增强对情绪刺激的记忆以及如何为情感的记忆 PTSD可能会改变中性刺激。 这些数据将提供 临床神经科学研究系统的基础 PTSD。