BRAIN ACTIVATION FOLLOWING FFT IN YOUTH AT RISK FOR BIPOLAR DISORDER

FFT 治疗后对有双相情感障碍风险的青少年进行大脑激活

• 批准号: 8362948
• 负责人: AMY S GARRETT
• 金额: $ 1.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362948
• 关键词: Adolescent; Annual Reports; Bipolar Disorder; Brain; Brain region; Data; Emotional; Face; Family; Family history of; Functional Magnetic Resonance Imaging; Funding; Grant; Magnetic Resonance; Magnetic Resonance Imaging; Manic; Measures; Mental Depression; Methods; National Center for Research Resources; Patients; Physiologic pulse; Principal Investigator; Process; Reading; Research; Research Infrastructure; Resources; Risk; Sample Size; Scanning; Source; Symptoms; Technology; United States National Institutes of Health; Visit; Youth; abstracting; cost; follow-up; high risk; response; treatment as usual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To investigate changes in brain activation associated with family focused treatment (FFT) in adolescents at high risk for developing bipolar disorder. Background: Previous studies have found that FFT is effective in stabilizing symptoms of mania and depression in adolescent patients. This treatment may also be associated with changes in the function of brain regions associated with emotional responses. Methods: Ten subjects with a family history of bipolar disorder and current subsyndromal symptoms completed scans at baseline and after 12 weeks of treatment (either treatment as usual or FFT). Functional magnetic resonance imaging scans were acquired using a spiral pulse sequence at 3T, while subjects viewed fearful and neutral faces. Whole brain data were processed in SPM5. Clusters of activation that changed significantly from baseline to follow-up were identified using a repeated measures ANOVA, and a dual threshold of p=.01, extent = 80. Mean activation in clusters that fell in a priori hypothesized regions was extracted. Due to the small sample size, all subjects were included in a single group, regardless of treatment condition. To read about other projects ongoing at the Lucas Center, please visit http://rsl.stanford.edu/ (Lucas Annual Report and ISMRM 2011 Abstracts)

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 目的：调查高中青少年的大脑激活变化（FFT） 患双相情感障碍的风险。 背景：先前的研究发现，FFT有效地稳定了躁狂和抑郁症状 青春期患者。 这种治疗也可能与与之相关的大脑区域功能的变化有关 情绪反应。 方法：十个患有躁郁症和当前次级症状家族史的受试者完成了扫描 基线和治疗12周后（像往常一样或FFT治疗）。功能磁共振成像 使用3T处的螺旋脉冲序列进行扫描，而受试者则观察到可怕的和中性的面孔。 全脑数据 在SPM5中处理。从基线到随访发生了显着变化的激活簇，使用A 重复测量方差分析和p = .01的双阈值，范围= 80。 提取了假设的区域。由于样本量较小，所有受试者都包含在一组中，无论如何 治疗条件。 要了解卢卡斯中心正在进行的其他项目，请访问http://rsl.stanford.edu/（卢卡斯年度报告和 ISMRM 2011摘要）