HEMATOPOIETIC PP14--AN ANTIINFLAMMATORY CYTOKINE

描述：PP14是一种抗炎细胞因子，由卵巢癌细胞分泌。 生殖道。季科辛斯基博士克隆了一种独特的分子 PP14在巨核细胞和血小板中产生，并已形成 PP14的原核和真核表达系统。他提议 (1)人造血型PP14及其疏水性的分子研究 配体和受体；(2)进一步表征人 造血型PP14及其免疫抑制功能的体外研究 (3)血小板PP14的造血活性及其潜能的研究 免疫病理结果；(4)体内功能的评估 动物模型系统中的PP14，在各自动物的预先克隆之后 PP14同源基因。将检验两个中心假设：(1)购买力平价14和， 特别是，人造血型PP14具有免疫治疗潜力 作为一种抗炎细胞因子用于治疗炎症 (2)来自血小板的PP14在某些情况下是免疫致病的 临床环境。

DESCRIPTION: PP14 is an anti-inflammatory cytokine secreted by cells of the reproductive tract. Dr. Tykocinski has cloned a unique molecular form of PP14 produced in megakaryocytes and platelets and has developed both prokaryotic and eukaryotic expression systems for PP14. He proposes (1) molecular studies of human hematopoietic PP14 and its hydrophobic ligands and receptors; (2) further characterization of human hematopoietic PP14 and its immunosuppressive functions in in vitro systems; (3) studies of hematopoietic PP14 in platelets and its potential immunopathological consequences; (4) assessment of in vivo functions of PP14 in animal model systems, after prior cloning of respective animal PP14 homologues. Two central hypotheses will be tested: (1) PP14 and, in particular, human hematopoietic PP14 has immunotherapeutic potential as an anti-inflammatory cytokine for the treatment of inflammatory disorders; (2) PP14 from platelets is immunopathogenic in certain clinical settings.