CARIBBEAN CORALS (PSEUDOPTEROGORIA) AS SOURCE OF NEW ANTIINFLAMMATORY AGENTS)

海洋无脊椎动物很早就被化学家发现了 作为新的生物医学物质的可能来源。药剂学家， 生理学家和生物化学家已经证明，其中许多 新型海洋产品以多种方式改变基本的生命过程 暗示了生物医学的应用。这些分子可以作为引线。 引导医药化工发展新业态 产品。这项研究专门针对加勒比海柳珊瑚 拟蕨属的八珊瑚作为一种可能的资源 新型抗炎天然产物。十五个人中只有六个 已知的柳珊瑚八珊瑚种类 对加勒比地区进行了化学评估，以确定其 代谢物组成。许多假蕨属物种已经 已被证明能产生具有有效抗炎作用的代谢物 活动。具体地说，在这项研究的四年期间，我们计划 仔细研究--五种以前未曾探索过的化学 文章题目波多黎各采集的柳珊瑚的种类。 用不同极性的溶剂(例如，正己烷， 二氯甲烷和甲醇)将通过细胞毒性进行监测 和抗炎活性检测。每一种柳珊瑚提取物 残基的化学结构特征也将通过1H- ~(13)C-核磁共振波谱。用层析进一步提纯 (柱、GC、LC)和分子结构的测定将继续进行 如果筛查结果有根据的话。结构的阐明将依赖于 主要依靠波谱方法(如~1H和~(13)C核磁共振、MS、IR、UV)和X- 光线衍射技术。

Marine invertebrates have been identified for a long time by chemists as likely sources of new biomedicinal substances. Pharmacologists, physiologists and biochemists have demonstrated that many of these novel marine products modify fundamental life processes in ways suggesting biomedical applications. These molecules can serve as leads to guide the pharmaceutical and chemical industries in developing new products. This research aims specifically at Caribbean gorgonian octocorals of the genus Pseudopterogorgia as a likely resource for novel anti-inflammatory natural products. Only six of the fifteen species of Pseudopterogorgia gorgonian octocorals known to exist in the Caribbean region have been assessed chemically for their secondary metabolite composition. Many Pseudopterogorgia species have already been shown to produce metabolites possessing potent anti-inflammatory activity. Specifically, during the four years of this research we plan to carefully scrutinize -the chemistry of five previously unexplored species of Pseudopterogorgia gorgonians collected in Puerto Rico. Initial extraction with solvents of different polarities (e.g., hexane, methylene chloride, and methanol) will be monitored using cytotoxicity and anti-inflammatory activity assays. Each of the gorgonian extract residues will also be screened for chemical structural features by 1H- and 13C-NMR spectroscopy. Further purification by chromatography (column, GC, LC) and determination of molecular structure will proceed if warranted by the screening results. Structure elucidation will rely heavily on spectral methods (e.g., 1H and 13C NMR, MS, IR, UV) and X- ray diffraction techniques.