The recirculation of myeloid dendritic cells

骨髓树突状细胞的再循环

• 批准号: DP190101851
• 负责人: Dr Helen Farrell
• 金额: $ 37.78万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-30 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101851
• 关键词: recirculation; myeloid; dendritic; cells

This project aims to understand dendritic cell recirculation. It will use virological tools to track dendritic cell migration, and identify key decision points. Expected outcomes include enhanced capacity in basic research and greater interdisciplinary collaboration between virology and immunology research groups. Significant benefits will include a new understanding of how G protein coupled receptor signalling and other tissue cues guide dendritic cell recirculation, and what consequences the recirculation has for immune cell function. This understanding will significantly advance our basic understanding of the immune system.

该项目旨在了解树突状细胞再循环。它将使用病毒学工具来跟踪树突状细胞迁移，并确定关键决策点。预期成果包括加强基础研究能力，加强病毒学和免疫学研究小组之间的跨学科合作。显著的益处将包括对G蛋白偶联受体信号传导和其他组织线索如何引导树突状细胞再循环以及再循环对免疫细胞功能的影响的新理解。这一认识将大大推进我们对免疫系统的基本理解。