The nature of standing genetic variation

常备遗传变异的本质

• 批准号: DP190101661
• 负责人: A/Prof Katrina McGuigan
• 金额: $ 32.91万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-03-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101661
• 关键词: nature; standing; genetic; variation

This project aims to expand understanding of the genetic variation underlying phenotypic differences among individuals. The nature of genetic variation has broad consequences across biology, from the detection of causal genetic variants to the adaptation of natural populations. This project will take a novel experimental approach to test several long-standing assumptions about the effects of new mutations on individual traits and their joint pleiotropic effect on fitness. By expanding our understanding of how mutation, selection and drift interact, this project could provide significant improvements in our understanding of the genetic basis of phenotypes, and our ability to predict phenotypic evolution.

该项目旨在扩大对个体间表型差异背后的遗传变异的理解。遗传变异的性质在生物学中具有广泛的影响，从检测致病性遗传变异到适应自然种群。该项目将采用一种新的实验方法来测试几个长期存在的假设，即新突变对个体性状的影响及其对适应性的联合多效性效应。通过扩展我们对突变、选择和漂移如何相互作用的理解，该项目可以显著改善我们对表型遗传基础的理解，以及我们预测表型进化的能力。