The nature of standing genetic variation

常备遗传变异的本质

• 批准号: DP190101661
• 负责人: A/Prof Katrina McGuigan
• 金额: $ 32.91万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-03-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101661
• 关键词: nature; standing; genetic; variation

This project aims to expand understanding of the genetic variation underlying phenotypic differences among individuals. The nature of genetic variation has broad consequences across biology, from the detection of causal genetic variants to the adaptation of natural populations. This project will take a novel experimental approach to test several long-standing assumptions about the effects of new mutations on individual traits and their joint pleiotropic effect on fitness. By expanding our understanding of how mutation, selection and drift interact, this project could provide significant improvements in our understanding of the genetic basis of phenotypes, and our ability to predict phenotypic evolution.

该项目旨在扩大对个体之间基础表型差异的遗传变异的理解。遗传变异的性质在生物学上具有广泛的后果，从因果遗传变异到自然种群的适应。该项目将采用一种新型的实验方法，以测试有关新突变对单个特征及其联合多效性对适应性的影响的几个长期假设。通过扩展我们对突变，选择和漂移如何相互作用的理解，该项目可以在我们对表型遗传基础的理解以及预测表型进化的能力方面提供重大改进。