The contribution of pleiotropic mutation to genetic variation and evolution

多效性突变对遗传变异和进化的贡献

• 批准号: DP150101643
• 负责人: A/Prof Katrina McGuigan
• 金额: $ 20.84万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150101643
• 关键词: contribution; pleiotropic; mutation; genetic; variation

This project aims to provide an in-depth characterization of pleiotropic effects across many traits, including fitness, in an outbred population of the fly, Drosophila serrata. The potential for one gene to affect many traits, pleiotropy, has been recognised for over 100 years. Pleiotropy is expected to underlie diverse biological phenomena, including evolution and age-related human diseases. Despite this, the contribution of pleiotropy to variation among individuals in appearance and in fitness remains poorly understood. By measuring the extent of pleiotropy and its fitness consequences, this project aims to advance understanding of how mutation and selection shape genetic variation and evolutionary potential in natural populations.

该项目旨在在许多特征（包括健身）的果蝇果蝇serrata中对多种特征（包括健身）的多效效应的深入表征。一个基因影响许多特征的潜力，即多效性，已确认已有100多年的认可。预计多种生物学现象是多种多样的生物学现象，包括进化和与年龄有关的人类疾病。尽管如此，多效性对外观和适应性的个体变异的贡献仍然很众所周知。通过测量多效性的程度及其适应性后果，该项目旨在提高对突变和选择如何影响自然种群中遗传变异和进化潜力的理解。