ARTERIAL BAROREFLEX CONTROL OF BLOOD PRESSURE EXERCISE

我们实验室中对人类的初步研究结果表明， 完全表征“开环”颈动脉压力感受性反射的能力 在较高的颈动脉窦扩张压力下操作（经典 重置）。在狗和人类中，主动脉的作用 压力感受器在运动中调节血压的作用 未知我们已经证明了人类的不同角色 主动脉和颈动脉压力感受器反射在调节血液 静止时的压力以及确定 心肺压力感受器和颈动脉压力反射。在 此外，这些反射和它们的相互作用的运作方式不同 在不同最大有氧能力水平的个体中， 有氧能力（VO-2 max），并可能在男性不同的操作 与女性相比。因此，我们假设这些信息 从颈动脉、主动脉和心肺压力感受器接收 是血压的主要调节剂， 人类的动态运动，这种关系是 由个人的有氧健身水平改变。为了 测试这些假设的不可靠性，我们将定义 刺激-反应关系和主动脉的相互作用。 稳态运动期间的颈动脉和心肺反射 在最大有氧能力高和低的个体中。许多 实验程序及其修改 在我们的实验室里已经开发了。 具体来说，我们将使用不同强度的稳态工作， 建立调节血压、颈部压力/吸力 颈动脉窦扰动技术，下体阴性 压力和急性容量扩张，以改变中心静脉 压力，以及非侵入性的药理学和机械手段 隔离主动脉压力感受器反射拟议的研究将 研究生理机制并确定性别 差异调查结果将提供重要的基线 关于各种压力感受器的相互作用的信息 人群在运动过程中的血压调节。

Pilot study findings from humans in our laboratory demonstrate our ability to fully characterize the "open-loop" carotid baroreflexes to operate at a higher carotid sinus distending pressure (classic resetting). in both dogs and humans the role of the aortic- baroreceptors in regulating blood pressure during exercise is unknown. We have documented in humans discrete differential roles of the aortic and carotid baroreceptor reflexes in regulating blood pressure at rest as well as identifying an interaction between cardiopulmonary baroreceptors and carotid baroreflexes. In addition, these reflexes and their interactions operate differently in individuals of differing levels of maximal aerobic capacity aerobic capacity (VO-2max) and may operate differently in men compared to women. Therefore, we hypothesize that information received from the carotid, aortic and cardiopulmonary baroreceptors are the principal modulators of systemic blood pressure during dynamic exercise in the human, and that this relationship is altered by the individual's level of aerobic fitness. In order to test the fallibility of these hypotheses, we will define the stimulus-response relationships and the interactions of the aortic. carotid and cardiopulmonary reflexes during steady-state exercise in individuals with high and low maximal aerobic capacities. Many of the experimental procedures and their modifications for use during exercise have been developed in our laboratory. Specifically, we will use different intensity steady-state work to establish a regulated blood pressure, neck pressure/suction techniques for perturbing the carotid sinus, lower body negative pressure and acute volume expansion to alter central venous pressure, and pharmacologic and mechanical means of non-invasively isolating the aortic baroreceptor reflex. The proposed studies will investigate the physiological mechanisms and will determine gender differences. The findings will provide important baseline information concerning the interactions of the various baroreceptor populations on the regulation of blood pressure during exercise.