EFFECT CA++ FOODS ON BONE QUALITY IN PUBERTAL FEMALES

CA 食物对青春期女性骨骼质量的影响

• 批准号: 2393948
• 负责人: JOAN LAPPE
• 金额: $ 7.5万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2393948
• 关键词: adolescence (12-20); body physical activity; bone density; bone development; clinical research; densitometry; developmental nutrition; diet therapy; dietary calcium; disease /disorder prevention /control; female; human puberty; human subject; human therapy evaluation; longitudinal human study; middle childhood (6-11); nursing intervention; nutrient intake activity; nutrition related tag

DESCRIPTION (Adapted from the Investigator's Abstract): Osteoporosis is a major public health concern. The application focuses on the problem early in life. Since there are no known safe, effective methods for restoring lost bone to the osteoporotic skeleton, prevention of osteoporosis is crucial. If skeletal development can be maximized during growth, young people will begin adulthood with optimal bone quality and be less likely to develop osteoporosis in later years. Yet bone health of children has not been adequately addressed. This proposal will build on 3 previous studies of bone quality in children. The aim of this experimental study is to test the effect of increasing dietary calcium intake to 1500 mg/day on increases in bone quality in pubertal females at age nine. The hypothesis to be tested is: pubertal females who consume a high calcium diet will have a greater increase bone quality, as measured by densitometry and ultrasound, than pubertal females who consume their usual dietary calcium intake. A convenience sample of 60 nine year old females will be randomly assigned to a treatment group given high calcium foods supplying 1500 mg/day for 4 years or a control group consuming their usual dietary calcium intake. Measurements of bone quality, bone mass, physical activity, dietary intake, height, weight, Tanner Stage, and medical history will be made at baseline, every three months, and at the end of the study. Evidence of a positive effect of increased calcium intake from food sources on bone quality in pubertal females will be followed by another proposal to determine if this treatment cohort can maintain their skeletal advantage into late adolescence. The overall long-term aim of the P.I.'s work is to test interventions designed to bring about conscious increase in calcium intake and physical activity in children that will improve their bone health and help to develop lifelong bone healthy behaviors.

描述（改编自研究者摘要）：骨质疏松症是一种 主要公共卫生问题。 应用尽早关注问题 在生活中。 由于目前还没有已知的安全、有效的恢复方法 骨质疏松骨骼失去骨质，预防骨质疏松 至关重要的。 如果在成长过程中骨骼发育能够最大化，那么年轻时 人们将以最佳的骨骼质量开始成年，并且不太可能 晚年出现骨质疏松症。 然而儿童的骨骼健康却没有得到改善 得到了充分的解决。 该提案将建立在之前的 3 项研究的基础上 儿童骨骼质量。 本实验研究的目的是测试 将膳食钙摄入量增加到 1500 毫克/天对增加的影响 九岁时青春期女性的骨质量。 假设为 测试结果是：青春期女性食用高钙饮食会出现 通过密度测定和超声波测量，骨质量得到更大程度的提高， 与平常膳食钙摄入量的青春期女性相比。 一个 60名九岁女性的方便样本将被随机分配到 治疗组每天给予高钙食物 1500 毫克，持续 4 年 或对照组消耗他们通常饮食中的钙摄入量。 骨质量、骨量、体力活动、饮食摄入量的测量， 将在基线时记录身高、体重、Tanner 阶段和病史， 每三个月一次，以及研究结束时一次。 积极的证据 增加食物中的钙摄入量对骨质量的影响 青春期女性将提出另一项建议，以确定这是否 治疗组可以将骨骼优势维持到晚期 青春期。 P.I. 工作的总体长期目标是测试 旨在有意识地增加钙摄入量的干预措施 儿童的体育活动将改善他们的骨骼健康 帮助养成终生骨骼健康的行为。