VACCINES ELICITING CD8 CYTOTOXIC T CELL RESPONSES

感染HIV-1的个体通常会产生强有力的抗病毒CD 8 细胞毒性T淋巴细胞（CTL）应答。 CTL似乎在扮演一个 在减少病毒载量方面起重要作用，但感染通常持续存在 最后变成了一堆垃圾。 该项目的长期目标是 促进疫苗的开发， 有效的CD 8 CTL应答比在自然免疫过程中发生的更有效。 感染 为此，我们将确定最有效的形式， 作为免疫原的热休克融合蛋白和DNA载体 有效的原发性和记忆性CD 8细胞毒性T淋巴细胞（CTL）应答， 一种转基因小鼠模型，目的是最终应用相关的 非人灵长类动物（猕猴？） 防止SIV感染。

Individuals infected with HIV-1 often make vigorous anti-viral CD8 cytotoxic T lymphocyte (CTL) responses. The CTL appear to play an important role in reducing the viral load but infection usually persists and eventually worsens. The long-term goal of this project to is facilitate the development of vaccines aimed at generating more effective CD8 CTL responses than occur in the course of natural infection. To this end we will define the maximally effective forms of heat shock fusion protein and DNA vectors as immunogens for eliciting potent primary and memory CD8 cytotoxic T lymphocyte (CTL) responses in a transgenic mouse model with aim of eventually applying related immunogens to the vaccination of nonhuman primates (macaque monkeys?) against SIV infection.