EFFECTS OF HIGH DOSE CDP-CHOLINE ON LEARNING IN SUBACUTE ISCHEMIC STROKE

高剂量 CDP-胆碱对亚急性缺血性中风学习的影响

• 批准号: 6246685
• 负责人: PAUL SPIERS
• 金额: $ 6.54万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246685
• 关键词: behavioral /social science research tag; cardiovascular disorder chemotherapy; choline; clinical research; clinical trials; cytosine nucleotides; dosage; drug screening /evaluation; human old age (65+); human subject; human therapy evaluation; ischemia; learning; placebos; stroke

Brain tissue repair following stroke requires turnover of old and production of new cell membranes. CDP-choline given to animals accelerates this process. In humans, CDP-choline improved level of consciousness in acute stroke. In elderly, CDP-cholne improved learning, particularly in "slow learners." This study will test the effect of high dose (2,000 mg. per day) CDP-choline in recovery of learning ability in ischemic stroke patients in a single center, parallel, matched smaple, double-blind, placebo-controlled 60-day trial.

中风后的脑组织修复需要旧的和 生产新的细胞膜。给动物注射CDP-胆碱 加速了这一过程。在人类中，CDP-胆碱提高了 急性卒中患者意识障碍。在老年人中，CDP-胆碱改善了学习， 尤其是在“学得慢的人”中。这项研究将测试的效果 高剂量(2,000 mgCDP-胆碱对学习能力恢复的影响 在缺血性中风患者中，在单个中心，平行，匹配的样本， 双盲、安慰剂对照、为期60天的试验。