EFFECTS OF HIGH DOSE CDP/CHOLINE ON LEARNING IN SUBACUTE ISCHEMIC STROKE

高剂量 CDP/胆碱对亚急性缺血性中风学习的影响

• 批准号: 6276795
• 负责人: PAUL SPIERS
• 金额: $ 5.37万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276795
• 关键词: cardiovascular disorder chemotherapy; choline; clinical research; clinical trials; cytosine nucleotides; dosage; drug screening /evaluation; human old age (65+); human subject; human therapy evaluation; ischemia; learning; placebos; stroke

Brain tissue repair following stroke requires turnover of old and production of new cell membranes. CDP-choline given to animals accelerates this process. In humans, CDP-choline improved level of consciousness in acute stroke. In elderly, CDP-cholne improved learning, particularly in "slow learners." This study will test the effect of high dose (2,000 mg. per day) CDP-choline in recovery of learning ability in ischemic stroke patients in a single center, parallel, matched sample, double-blind, placebo-controlled 60-day trial.

中风后的脑组织修复需要旧的和 产生新的细胞膜。 CDP-胆碱给予动物 加速了这个过程。 在人类中，CDP-胆碱提高了 急性中风的意识 在老年人中，CDP-胆碱改善了学习， 特别是在“慢学习者”中。“这项研究将测试高血压的影响， 剂量（2，000 mg. CDP-胆碱在学习能力恢复中的作用 单中心、平行、匹配样本中的缺血性卒中患者， 双盲安慰剂对照60天试验。