EFFECT OF TRIMETHOPRIM ON POTASSIUM METABOLISM

甲氧苄啶对钾代谢的影响

• 批准号: 6246615
• 负责人: BURL R DON
• 金额: $ 3.14万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-03 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246615
• 关键词: drug adverse effect; drug interactions; drug screening /evaluation; electrolyte balance; human subject; potassium; trimethoprim

Recent studies have noted that trimethoprim blocks sodium channels in the nephron resulting in impaired potassium excretion. Retrospective clinical studies in AIDS patients have noted that high dose therapy with sulfamethoxasole/trimethoprim was associated with increases in serum potassium concentration and discontinuation of the drug resulted in a decrease in serum potassium concentration. The purpose of this study is to evaluate the effects of trimethoprim on potassium balance in normal control subjects. In addition, the effect of this drug on the renin- angiotensin-aldosterone axis will be evaluated.

最近的研究指出，甲氧苄啶阻断钠通道， 肾单位导致钾排泄受损。 回顾性临床 对艾滋病患者的研究指出， 磺胺甲恶唑/甲氧苄啶与血清中 钾浓度和停药导致 血清钾浓度降低。 本研究旨在 评价甲氧苄啶对正常人钾平衡的影响 控制对象。 此外，该药物对肾素的作用- 将评价血管紧张素-醛固酮轴。