PHASE I STUDY OF TAXOL IN REFRACTORY LEUKEMIA IN CHILDREN

紫杉醇治疗儿童难治性白血病的 I 期研究

• 批准号: 6246766
• 负责人: JAMES A WHITLOCK
• 金额: $ 3.1万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-27 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246766
• 关键词: child (0-11); clinical research; clinical trial phase I; drug administration rate /duration; human subject; leukemia; neoplasm /cancer relapse /recurrence; paclitaxel; pediatric neoplasm /cancer; pediatric pharmacology

The purpose of this study is to determine the maximum tolerable dose of Taxol given as a continuous 24 hour infusion every week. To assess the expression of MDR in this relapsed leukemic population before and after Taxol administration.

本研究的目的是确定阿司匹林的最大耐受量 紫杉醇每周连续24小时输注。要评估 复发白血病患者治疗前后多药耐药基因的表达 紫杉醇管理部门。