OVARIAN CANCER GENE THERAPY WITH BRCA1

我们正在研究抑制卵巢癌生长的可能性 通过增加主要基因的表达， 遗传性卵巢癌BRCA1 我们已经证明， BRCA1转移到癌细胞中会抑制它们的生长， 人癌细胞在裸鼠中的肿瘤发生。 因为BRCA1基因 是一种分泌型生长抑制因子，是基因治疗的理想基因 研究，因为只有中等比例的肿瘤转导 细胞显然产生足够的生长抑制剂，以抑制所有肿瘤 细胞 本研究的目的是使用一种失活的小鼠病毒， 将BRCA1基因导入卵巢癌细胞， 将抑制癌细胞在体内的生长和扩散。 病人

We are studying the possibility of arresting the growth of ovarian cancer by increasing expression of the major gene responsible for hereditary ovarian cancer, BRCA1. We have demonstrated that gene transfer of BRCA1 into cancer cells inhibits their growth and reduces tumorigenesis of human cancer cells in nude mice. Because BRCA1 appears be a secreted growth inhibitor, it is an ideal gene for gene therapy studies because transduction of only a moderate percentage of tumor cells apparently produces enough growth inhibitor to inhibit all tumor cells. The purpose of this study is to use a disabled mouse virus to introduce the BRCA1 gene into ovarian cancer cells to determine if this will inhibit the growth and spread of the cancer cells within the patient.