EXTRACELLULAR ADENOSINE DEAMINASE IN SICKLE CELL DISEASE

镰状细胞病中的细胞外腺苷脱氨酶

• 批准号: 6246656
• 负责人: MARIA KOEHLER
• 金额: $ 1.91万
• 依托单位: CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246656
• 关键词: adenosine deaminase; clinical research; enzyme activity; extracellular; hemolysis; human subject; sickle cell anemia; sickle cell crisis

Sickle cell disease (SCD) is associated with a continuing level of hemolysis, and during a "painful crisis" the degree of hemolysis is increased. It is possible that release of adenosine deaminase from RBCs during hemolysis decreases extracellular levels of adenosine leading to a pro-vaso-occlusive state which triggers a painful crisis. This hypothesis is strengthened by our recent in vivo animal studies demonstrating that DMSO induced hemolysis results in massive release of adenosine deaminase with the complete disappearance of urinary adenosine. The purpose of this protocol is to study the effect of adenosine deaminase changes in patients with sickle cell disease.

镰状细胞病（SCD）与持续水平的 溶血，并且在“痛苦的危机”期间，溶血的程度是 增加 红细胞中腺苷脱氨酶的释放可能与红细胞中腺苷脱氨酶的释放有关， 在溶血过程中，腺苷的细胞外水平降低， 引发痛苦危机的血管阻塞状态 这一假设 我们最近的体内动物研究证实， DMSO诱导的溶血导致腺苷脱氨酶的大量释放 尿腺苷完全消失 这样做的目的 方案是研究腺苷脱氨酶变化对患者的影响， 镰状细胞病。