DATRI 020 EFFECT OF ACYCLOVIR FOR HERPES SIMPLEX VIRUS ON BLOOD HIV VIRAL LOAD

DATRI 020 阿昔洛韦治疗单纯疱疹病毒对血液 HIV 病毒载量的影响

• 批准号: 6246889
• 负责人: MARY VOGLER
• 金额: $ 2.39万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-12 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246889
• 关键词: Alphaherpesvirinae; Herpes simplex disease; T lymphocyte; acyclovir; clinical research; clinical trials; cytokine; drug screening /evaluation; human subject; human therapy evaluation; leukocyte activation /transformation; protein biosynthesis; virus load

The purpose of this pilot study is to characterize the change in plasma HIV RNA levels and other measures of HIV burden during and after a course of acyclovir treatment for acute Herpes Simplex Virus (HSV) infection. A secondary objective is to charaterize the effect of acyclovir on T cell activation and cytokine production during and after the course of acyclovir treatment and to determine the relationship between changes in these parameters and changes in HIV burden.

这项初步研究的目的是表征血浆中的变化 疗程期间和疗程后的HIV RNA水平和其他HIV负荷指标 阿昔洛韦治疗急性单纯疱疹病毒（HSV）感染。一 其次是观察阿昔洛韦对T细胞的影响， 活化和细胞因子的产生过程中和之后 并确定阿昔洛韦治疗前后变化的关系 这些参数和艾滋病毒负担的变化。