DATRI 020 EFFECT OF ACYCLOVIR FOR HERPES SIMPLEX VIRUS ON BLOOD HIV VIRAL LOAD

DATRI 020 阿昔洛韦治疗单纯疱疹病毒对血液 HIV 病毒载量的影响

• 批准号: 6115743
• 负责人: MARY VOGLER
• 金额: $ 2.31万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6115743
• 关键词: Alphaherpesvirinae; Herpes simplex disease; T lymphocyte; acyclovir; clinical research; clinical trials; cytokine; drug screening /evaluation; human subject; human therapy evaluation; leukocyte activation /transformation; protein biosynthesis; virus load

The purpose of this pilot study is to characterize the change in plasma HIV RNA levels and other measures of HIV burden during and after a course of acyclovir treatment for acute Herpes Simplex Virus (HSV) infection. A secondary objective is to charaterize the effect of acyclovir on T cell activation and cytokine production during and after the course of acyclovir treatment and to determine the relationship between changes in these parameters and changes in HIV burden.

这项初步研究的目的是表征血浆中的变化 艾滋病毒RNA水平和艾滋病毒负荷的其他措施期间和之后， 急性单纯疱疹病毒（HSV）的治疗 感染第二个目标是表征 阿昔洛韦对T细胞活化和细胞因子产生的影响 无环鸟苷治疗过程并确定关系 这些参数的变化和艾滋病毒负担的变化之间的关系。