ECOLOGY OF EMERGING ARENAVIRUSES IN SOUTHWESTERN U S

美国西南部新兴沙粒病毒的生态学

• 批准号: 2370684
• 负责人: CHARLES F FULHORST
• 金额: $ 24.82万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2370684
• 关键词: Arenaviridae; Rodentias; United States; biochemical evolution; communicable disease transmission; disease /disorder proneness /risk; disease carrier state; disease vectors; ecology; enzyme linked immunosorbent assay; epidemiology; field study; genetic polymorphism; genotype; host organism interaction; human tissue; nucleic acid sequence; pathologic process; serology /serodiagnosis; virulence; virus antigen; virus diseases

The broad objectives of this research proposal are to elucidate the ecology, vertebrate host associations, genetic diversity and human disease potential of arenaviruses present in the southwestern United States and northern Mexico. The recent identification of a new arenavirus, Whitewater Arroyo (WWA), infecting rodents in New Mexico and serologic evidence that WWA or related arenaviruses are widely distributed in woodrat (Neotoma spp.) populations throughout the Southwest, raise the real possibility that these agents may be of some public health importance in the region. The specific aims of this project are (l) to determine the geographic distribution and rodent host associations of WWA virus in the Southwestern U.S. and northern Mexico; (2) to study the genetic associations among various woodrat species-and arenaviruses occurring in the same region; (3) to investigate the pathogenesis of WAA virus in its presumed natural rodent host, N albigula; and (4) to determine the prevalence, risk factors and disease associations of infection with WWA and related arenaviruses among humans living in the endemic region. This research is a collaborative effort between scientists at the University of Texas Medical Branch (Galveston) and Texas Tech University (Lubbock). The project is of 3 years duration, consists of both field and laboratory studies, and involves the disciplines of virology, pathology, molecular biology, genetics, mammalogy, ecology and epidemiology.

该研究建议的广泛目标是阐明 生态学，脊椎动物宿主协会，遗传多样性和人类 西南联队中存在的竞技病毒的疾病潜力 国家和墨西哥北部。最近确定了一个新的 Arenavirus，Whitewater Arroyo（WWA），在新的 墨西哥和血清学证据表明WWA或相关的体育症病毒是 在整个伍德拉特（Neotoma spp。）种群中广泛分布 西南，提高了这些代理商可能是 该地区一些公共卫生的重要性。这个特定的目的 项目是（L）确定地理分布和啮齿动物 美国西南部和北部的WWA病毒的托管协会 墨西哥; （2）研究各种伍德拉特的遗传关联 物种和体轨道病毒发生在同一地区； （3）到 研究WAA病毒在其假定的天然中的发病机理 啮齿动物主持人，n albigula； （4）确定患病率，风险 感染与WWA及相关的因素和疾病关联 居住在流行地区的人类中的体ar虫。这项研究 是德克萨斯大学科学家之间的合作努力 医学分支（加尔维斯顿）和德克萨斯理工大学（Lubbock）。 该项目持续3年，包括现场和实验室 研究，涉及病毒学，病理学，分子的学科 生物学，遗传学，哺乳动物，生态学和流行病学。