ECOLOGY OF EMERGING ARENAVIRUSES IN SOUTHWESTERN U.S.

美国西南部新兴沙粒病毒的生态学

• 批准号: 6532731
• 负责人: CHARLES F FULHORST
• 金额: $ 32.64万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6532731
• 关键词: Arenaviridae; Peromyscus; Rodentias; United States; communicable disease transmission; cooperative study; disease /disorder proneness /risk; disease carrier state; disease vectors; ecology; emerging infectious disease; enzyme linked immunosorbent assay; epidemiology; field study; genetic polymorphism; genotype; host organism interaction; human tissue; nucleic acid sequence; pathologic process; phenotype; polymerase chain reaction; serology /serodiagnosis; tissue /cell culture; virulence; virus diseases

DESCRIPTION (Adapted from the Applicant's Abstract): The broad objective of the proposed research is to advance our knowledge on the epidemiology of arena viruses associated with rodents native to the southern United States. Knowledge of the rodent host relationship (including duration and magnitude of virus shedding in infected rodents) and geographical distribution of infected rodents is essential to an accurate understanding of the human diseases caused by arena viruses. Recent studies provided the first unequivocal evidence that arena viruses are geographically widely distributed u the southern U.S. in associateion with rodents belonging to the genera Neotome, Peromyscus and Sigmodon. The specific aims of the proposed research are to: 1) Extend our knowledge on the geographic range, rodent host relationship, genotypic diversity off arena viruses naturally associated with signodontine rodents in the southern U.S.; 2) refine our knowledge on the ecology of Whitewater Arroyo (WWA) and Bear Canyon (BCN) viruses; 3) investigate the pathogenesis of WWA and BCN viruses inb their principal rodent hosts (Neotoma and Permyscus rodents, respectively); 4) assess whether knowledge of the phylogenetic history of North American rodents can be used to accurately predict the geographic range and rodent host associations of the various area viruses indigenous to the southern U.S.; and, 5) investigate further the human health significance of North American rodent-borne arena viruses.

描述（改编自申请人的摘要）： 拟议的研究是提高我们对竞技场流行病学的了解 与美国南部的啮齿动物相关的病毒。知识 啮齿动物宿主关系（包括病毒的持续时间和大小 受感染啮齿动物的脱落）和受感染啮齿动物的地理分布 对于对竞技场引起的人类疾病的准确理解至关重要 病毒。最近的研究提供了第一个明确的证据 病毒在地理上广泛分布在美国南部 与属于属属的啮齿动物的关联，peromyscus和 Sigmodon。拟议研究的具体目的是：1）扩展我们 关于地理范围，啮齿动物宿主关系，基因型的知识 竞技场病毒的多样性自然与Signodontine啮齿动物有关 美国南部； 2）完善我们对白水Arroyo生态学的知识 （WWA）和熊峡谷（BCN）病毒； 3）研究WWA和 BCN病毒INB其主要啮齿动物宿主（Neotoma和Permyscus啮齿动物， 分别）; 4）评估是否了解北方的系统发育史 美国啮齿动物可用于准确预测地理范围和 啮齿动物寄主协会的各个地区病毒土著 我们。; 5）进一步研究北方的人类健康意义 美国啮齿动物传播的竞技场病毒。