A modular synthetic biology pipeline for the engineering of next generation sustainable and bioactive dyes

用于下一代可持续和生物活性染料工程的模块化合成生物学管道

• 批准号: 72672
• 金额: $ 50.08万
• 依托单位: COLORIFIX LIMITED
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=72672
• 关键词: modular; synthetic; biology; pipeline; engineering

Critical for the success of any brand in the Textile industry is the dyeing process with a requirement for colours to demonstrate uniformity, resistance and economic viability. These requirements however come at a significant environmental and societal cost with the industry globally recognised as one of the most environmentally polluting Industrial processes, consuming \> 1.3 million tons of dyes and pigments p.a, the most common of which are synthetic azo dyes derived from petrochemical sources. These dyes are however highly toxic and bioaccumulative with some 200K tons lost annually in effluent, most escaping conventional wastewater treatment with textile dyeing accounting for over 20% of global industrial water pollution The industry is also one of the largest industrial water consumers with over 5.8 trillion litres of water consumed p.a.Failed attempts to ban certain Azo dyes and control the release of toxic wastewaters, have placed significant pressure on the Textile industry for alternative dyeing methods as part of a global consumer and increasing regulatory demand for greater sustainability in production techniques. As a result, the market has seen a flux of 'natural dyes' growing rapidly in the $9.8 billion/year dye market. However, such dyes are rarely 'low-impact' often using mordants to "fix" colour onto the fabric and still consuming large quantities of water.Based on advancements in synthetic biology, Colorifix offer an ecological and sustainable alternative to conventional dyeing techniques by converting low-cost commonly available agricultural by-products such as sugar molasses into high-value pigments and dyed textiles. All of this can be done without any acids, heavy metals or solvents as required in conventional dyeing. The Colorifix process also uses 10 times less water and up to 80% less energy.With significant brand interest secured, and with Innovate UK support, Colorifix aim to deliver 18-month programme of Industrial Research in collaboration with the Earlham Institute to investigate the potential to scale production using industrial_Pseudomonas_ species as a replacement for traditional_Escherichia coli_ -_Pseudomona__s_ offering a metabolically versatile bacterium and an exceptional host for the expression of complex natural products but limited in its inability to degrade sucrose-based renewable feedstocks. These activities will enable Colorifix to truly scale the process and capitalise upon the Global market opportunity available. The arising knowledge also add significant value and open new opportunities to manufacture antiviral and antimicrobial dyes due to the reported therapeutic potential of anthraquinones.

在纺织行业中，任何品牌成功的关键是染色过程，要求颜色表现出均匀性，抗性和经济可行性。然而，这些要求带来了巨大的环境和社会成本，因为该行业是全球公认的最污染环境的工业过程之一，每年消耗130万吨染料和颜料，其中最常见的是来自石化来源的合成偶氮染料。然而，这些染料具有剧毒和生物蓄积性，每年在废水中损失约20万吨，其中大多数是传统的纺织染色废水处理，占全球工业水污染的20%以上。该行业也是最大的工业用水户之一，消耗了超过5.8万亿升的水。作为全球消费者的一部分，对纺织工业施加了巨大的压力，要求采用替代染色方法，并增加了对生产技术更大可持续性的监管要求。因此，在每年98亿美元的染料市场中，“天然染料”的流动性迅速增长。然而，这种染料很少是“低影响”的——通常使用媒染剂将颜色“固定”在织物上，并且仍然消耗大量的水。Colorifix基于合成生物学的进步，通过将低成本的常见农业副产品（如糖蜜）转化为高价值的色素和染色纺织品，为传统染色技术提供了一种生态和可持续的替代方案。所有这些都可以在没有任何酸、重金属或溶剂的情况下完成，这是传统染色所需要的。Colorifix工艺还可以减少10倍的用水量和高达80%的能耗。有了重要的品牌利益保障，有了创新英国的支持，Colorifix的目标是与Earlham研究所合作开展为期18个月的工业研究项目，研究利用工业假单胞菌替代传统的工业假单胞菌进行规模化生产的潜力。工业假单胞菌提供了一种代谢多样的细菌和一种特殊的宿主，可以表达复杂的天然产物，但它无法降解基于糖的可再生原料。这些活动将使Colorifix能够真正扩大流程并利用现有的全球市场机会。由于报道了蒽醌的治疗潜力，新出现的知识也增加了重要的价值，并为制造抗病毒和抗菌染料开辟了新的机会。