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CALCIUM DEPENDENT MECHANISMS IN APOPTOSIS

CALCIUM DEPENDENT MECHANISMS IN APOPTOSIS
细胞凋亡中的钙依赖性机制
批准号：
2376993
负责人：
David J. McConkey
金额：
$10.13万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-07-15 至 2002-04-30
来源：
https://reporter.nih.gov/project-details/2376993
关键词：
apoptosis calcium flux cell line chemical cleavage clone cells enzyme activity gene expression inositol phosphates molecular cloning protein kinase protooncogene receptor expression

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中文摘要
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描述（改编自研究者摘要）：当私家侦探和其他人
英文摘要
DESCRIPTION (adapted from investigator's abstract): While the PI and others in the field have demonstrated a requirement for altered intracellular calcium levels in the regulation of apoptosis, little data are available regarding the intracellular targets for this factor. A calcium regulated protease has been identified by the PI from the nucleus that appears to be required for both lamin B degradation and DNA fragmentation. The PI has also demonstrated that there is a caspase cleavage consensus sequence in the IP3 receptor. This proposal is designed to: 1) identify the calcium-activated protease required for thymocyte apoptosis; 2) determine if the anti-apoptotic protein bcl-2 regulates this proteases and 3) determine if the type 1 IP3 receptor is required for apoptosis.
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