CALCIUM DEPENDENT MECHANISMS IN APOPTOSIS
CALCIUM DEPENDENT MECHANISMS IN APOPTOSIS
批准号:
6172940
负责人:
David J. McConkey
金额:
$10.78万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-07-15 至 2002-04-30
中文摘要
描述(改编自研究者摘要):PI和其他人
已经证明需要改变细胞内
钙水平在细胞凋亡的调节,很少有数据可用
关于这个因子的细胞内靶点。 钙调节
蛋白酶已经被PI从细胞核中鉴定出来,
核纤层蛋白B降解和DNA片段化都需要。 主要研究者有
也证明了在细胞中存在半胱天冬酶切割共有序列,
IP 3受体。 该建议旨在:1)确定
胸腺细胞凋亡所需的钙激活蛋白酶; 2)确定是否
抗凋亡蛋白bcl-2调节这种蛋白酶,以及3)确定
如果1型IP 3受体是凋亡所必需的。
英文摘要
DESCRIPTION (adapted from investigator's abstract): While the PI and others
in the field have demonstrated a requirement for altered intracellular
calcium levels in the regulation of apoptosis, little data are available
regarding the intracellular targets for this factor. A calcium regulated
protease has been identified by the PI from the nucleus that appears to be
required for both lamin B degradation and DNA fragmentation. The PI has
also demonstrated that there is a caspase cleavage consensus sequence in the
IP3 receptor. This proposal is designed to: 1) identify the
calcium-activated protease required for thymocyte apoptosis; 2) determine if
the anti-apoptotic protein bcl-2 regulates this proteases and 3) determine
if the type 1 IP3 receptor is required for apoptosis.
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Proteasome Inhibition and ER Stress
-
批准号:8204790
-
项目类别:
-
资助金额:$24.8万
-
财政年份:2009
-
负责人:David J. McConkey
-
依托单位:
Proteasome Inhibition and ER Stress
-
批准号:8008803
-
项目类别:
-
资助金额:$24.8万
-
财政年份:2009
-
负责人:David J. McConkey
-
依托单位:
Proteasome Inhibition and ER Stress
-
批准号:7752518
-
项目类别:
-
资助金额:$25.56万
-
财政年份:2009
-
负责人:David J. McConkey
-
依托单位:
Proteasome Inhibition and ER Stress
-
批准号:8388812
-
项目类别:
-
资助金额:$23.31万
-
财政年份:2009
-
负责人:David J. McConkey
-
依托单位:
Proteasome Inhibition and ER Stress
-
批准号:7590692
-
项目类别:
-
资助金额:$25.56万
-
财政年份:2009
-
负责人:David J. McConkey
-
依托单位:
Death Receptors in Bladder Cancer Therapy
-
批准号:7729506
-
项目类别:
-
资助金额:$18.6万
-
财政年份:2008
-
负责人:David J. McConkey
-
依托单位:
In situ detection of apoptosis in tumor endothelial cells
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批准号:6563959
-
项目类别:
-
资助金额:$29.68万
-
财政年份:2002
-
负责人:David J. McConkey
-
依托单位:
In situ detection of apoptosis in tumor endothelial cells
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批准号:6499809
-
项目类别:
-
资助金额:$29.68万
-
财政年份:2001
-
负责人:David J. McConkey
-
依托单位:
CALCIUM DEPENDENT MECHANISMS IN APOPTOSIS
-
批准号:2376993
-
项目类别:
-
资助金额:$10.13万
-
财政年份:1997
-
负责人:David J. McConkey
-
依托单位:
CALCIUM DEPENDENT MECHANISMS IN APOPTOSIS
-
批准号:2700661
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项目类别:
-
资助金额:$10.32万
-
财政年份:1997
-
负责人:David J. McConkey
-
依托单位:
APOPTOSIS IN PULMONARY FIBROSIS
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批准号:2658170
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项目类别:
-
资助金额:$7.35万
-
财政年份:1997
-
负责人:David J. McConkey
-
依托单位:
CALCIUM DEPENDENT MECHANISMS IN APOPTOSIS
-
批准号:2895476
-
项目类别:
-
资助金额:$10.51万
-
财政年份:1997
-
负责人:David J. McConkey
-
依托单位:
CALCIUM DEPENDENT MECHANISMS IN APOPTOSIS
-
批准号:6376213
-
项目类别:
-
资助金额:$11.12万
-
财政年份:1997
-
负责人:David J. McConkey
-
依托单位:
JOINT TSU/UT TRAINING PROGRAM TO STUDY TOXIC MECHANISMS
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批准号:2872309
-
项目类别:
-
资助金额:$20.09万
-
财政年份:1996
-
负责人:David J. McConkey
-
依托单位:
JOINT TSU/UT TRAINING PROGRAM TO STUDY TOXIC MECHANISMS
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批准号:6150707
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项目类别:
-
资助金额:$21.38万
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财政年份:1996
-
负责人:David J. McConkey
-
依托单位:
Death Receptors in Bladder Cancer Therapy
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批准号:8135638
-
项目类别:
-
资助金额:$23.92万
-
财政年份:--
-
负责人:David J. McConkey
-
依托单位:
Death Receptors in Bladder Cancer Therapy
-
批准号:7932246
-
项目类别:
-
资助金额:$24.16万
-
财政年份:--
-
负责人:David J. McConkey
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依托单位:
海外基金