CENTRAL NEURAL CONTROL OF GASTRIC MUCOSAL DEFENSE

胃粘膜防御的中枢神经控制

基本信息

项目摘要

Administration of neurotensin (NT) into the dopamine (DA)-containing nuclei of the mesolimbic system; nucleus accumbens (NACB) and ventral tegmental area (VTA); in the brain inhibits gastric acid secretion and affords gastric mucosal protection against cold water restraint (CWR) induced gastric mucosal injury. The unifying hypothesis is that CWR- induced hypothermia reduces NT activity in the mesolimbic system by reducing NT message, causing a reduction of dopamine activity and a reduction in alpha and beta adrenergic activity in these nuclei resulting in either increased vagal tone or decreased sympathetic tone which will then result in increased rates of gastric acid secretion or reduced endogenous mucosal prostaglandin synthesis. The proposed studies will better define l) the effect of CWR on mesolimbic levels of NT, DA, and NT mRNA and the B-max and K-D for NT and DA receptors; 2) the role played by central adrenergic and dopaminergic receptor activation; and 3) the mechanism(s) by which NT enhances gastric mucosal prostaglandin activity. Concentrations of mesolimbic NT, DA, and NT mRNA, and NT and DA receptor number (B-max) and affinity (K-D) will be measured at various time intervals (15-120 min) during CWR and following the stereotaxic administration of a NT, DA or specific receptor antagonists into the NACB or VTA. These studies will provide information regarding the role of NT in the mesolimbic nuclei during CWR and control of NT and DA receptor activity during CWR. Central (mesolimbic) or systemic pretreatment with alpha1, alpha2, beta1, beta2, DA1, or DA2 receptor agonists, antagonists, and truncal vagotomy before 1) central NT administration followed by CWR; or 2) pentagastrin administration will provide information regarding the role of central adrenergic and dopaminergic mediation of antisecretory and protective effects of central NT. The effect of specific pharmacological dopaminergic, adrenergic, and truncal vagotomy preceding central NT administration, on gastric mucosal prostaglandin generation will provide information regarding the potential mechanism(s) by which central NT enhances gastric mucosal prostaglandin generation. These studies will enhance our understanding of central control of gastric mucosal function and may provide new avenues through which mucosal defense mechanisms can be enhanced.
给药神经紧张素(NT)进入含多巴胺(DA)

项目成果

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GORDON L KAUFFMAN其他文献

GORDON L KAUFFMAN的其他文献

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{{ truncateString('GORDON L KAUFFMAN', 18)}}的其他基金

CENTRAL NEURAL CONTROL OF GASTRIC MUCOSAL DEFENSE
胃粘膜防御的中枢神经控制
  • 批准号:
    2140315
  • 财政年份:
    1987
  • 资助金额:
    $ 19.22万
  • 项目类别:
CENTRAL NEURAL CONTROL OF GASTRIC MUCOSAL DEFENSE
胃粘膜防御的中枢神经控制
  • 批准号:
    3237462
  • 财政年份:
    1987
  • 资助金额:
    $ 19.22万
  • 项目类别:
CENTRAL NEURAL CONTROL OF GASTRIC MUCOSAL DEFENSE
胃粘膜防御的中枢神经控制
  • 批准号:
    2770371
  • 财政年份:
    1987
  • 资助金额:
    $ 19.22万
  • 项目类别:
CENTRAL NEURAL CONTROL OF GASTRIC MUCOSAL DEFENSE
胃粘膜防御的中枢神经控制
  • 批准号:
    3237457
  • 财政年份:
    1987
  • 资助金额:
    $ 19.22万
  • 项目类别:
CENTRAL NEURAL CONTROL OF GASTRIC MUCOSAL DEFENSE
胃粘膜防御的中枢神经控制
  • 批准号:
    2140316
  • 财政年份:
    1987
  • 资助金额:
    $ 19.22万
  • 项目类别:
CENTRAL NEURAL CONTROL OF GASTRIC MUCOSAL DEFENSE
胃粘膜防御的中枢神经控制
  • 批准号:
    3237463
  • 财政年份:
    1987
  • 资助金额:
    $ 19.22万
  • 项目类别:
CARDIOVASCULAR DETERMINANTS OF CATECHOLAMINE RELEASE
儿茶酚胺释放的心血管决定因素
  • 批准号:
    3335719
  • 财政年份:
    1977
  • 资助金额:
    $ 19.22万
  • 项目类别:
PROSTAGLANDIN ACTIVITY AND CONTROL OF GASTRIC MUCOSAL BLOOD FLOW
前列腺素活性和胃粘膜血流控制
  • 批准号:
    4689064
  • 财政年份:
  • 资助金额:
    $ 19.22万
  • 项目类别:

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    2003
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Inhaled dopamine agonists for late stage Parkinsonism
吸入多巴胺激动剂治疗晚期帕金森病
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    6914942
  • 财政年份:
    2003
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  • 财政年份:
    2000
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  • 财政年份:
    2000
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    $ 19.22万
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DOPAMINE AGONISTS AS INHIBITORS OF PROLACTIN SYNTHESIS
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  • 批准号:
    6120219
  • 财政年份:
    1999
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    6217783
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    $ 19.22万
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    1999
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    $ 19.22万
  • 项目类别:
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