权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

CARDIOVASCULAR DETERMINANTS OF CATECHOLAMINE RELEASE

儿茶酚胺释放的心血管决定因素

基本信息

批准号：
3335719
负责人：
GORDON L KAUFFMAN
金额：
$ 23.38万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
起止时间：
1977-09-01 至 1992-11-30
项目状态：
已结题

项目摘要

Evaluation of the role of Prostaglandin E2 (PGE2) delivered systemically as intravenously infused PGE2 and centrally by ventriculo-cisternal perfusion in controlling centrally mediated, Angiotensin II dependent, reflexly excited adrenal medullary catecholamine release in acutely anephric dogs are our goals for the next grant period. In anesthetized, heparinized dogs following acute nephrectomy and placement of adreno-femoral shunts and aortic cannulae we will study the dose responsiveness of intravenous PGE2's ability to restore normal adrenal reflex catecholamine release elicited by acute hemorrhage. With an appropriate sub-systemic threshold dose of PGE2 derived from that data, we then will perfuse ventriculo-cisternal PGE2 in anesthetized acutely anephric dogs with threshold quantities of PGE2 on reflex catecholamine release following hemorrhage. Finally, we will infuse, ventriculo-cisternally, Angiotensin II and PGE2 concomitantly to define the central effect of PGE2 on Angiotensin II responsiveness. Ventriculo-cisternally perfused PGE2 will be evaluated in two different ways; in one set of experiments, I.V. Angiotensin and ventriculo-cisternally perfused PGE2 will both be given and in another set of experiments, PGE2 and Angiotensin II will be given concominantly in the ventriculo-cisternal perfusion circuit. Understanding the neuro-hormonal control reflex catecholamine release is one long-term objective; another related goal is understanding whether or not renal hormones, specifically renin and the Angiotensin II generated under its infuence and PGE2, are needed to support central nervous system reflex activity. Such physiologic insights will, we hope, help us understand disordered central nervous system mechanisms involved in clinical hypertension.

系统输送的前列腺素 E2 (PGE2) 作用的评估静脉注射 PGE2 并通过脑室池灌注进行集中注射控制中枢介导的血管紧张素 II 依赖性反射急性肾病犬肾上腺髓质儿茶酚胺释放兴奋是我们下一个资助期的目标。在麻醉、肝素化的狗中急性肾切除术和肾上腺股分流术后主动脉插管，我们将研究静脉注射 PGE2 的剂量反应恢复正常肾上腺反射儿茶酚胺释放的能力急性出血。具有适当的 PGE2 亚系统阈剂量根据该数据，我们将灌注脑室池 PGE2 用阈值量的 PGE2 麻醉急性肾病狗出血后反射性儿茶酚胺释放。最后，我们将脑室池同时输注血管紧张素 II 和 PGE2 定义 PGE2 对血管紧张素 II 反应性的中心作用。脑室池灌注 PGE2 将在两种不同的情况下进行评估方式；在一组实验中，I.V.血管紧张素和心室池灌注 PGE2 将同时给予并在另一组中实验中，PGE2 和血管紧张素 II 将同时给予脑室池灌注回路。了解神经激素控制儿茶酚胺反射释放是长期目标之一；其他相关目标是了解肾激素是否，特别是肾素及其影响下生成的血管紧张素 II 和 PGE2 是支持中枢神经系统反射活动所需。这样的生理我们希望这些见解能够帮助我们理解中枢神经紊乱临床高血压的系统机制。