Methodology for Producing New Heterocyclic Building Blocks for Drug Synthesis

用于药物合成的新型杂环结构单元的生产方法

• 批准号: 730011
• 金额: $ 10.62万
• 依托单位: DURHAM ORGANICS LIMITED
• 依托单位国家: 英国
• 项目类别: Legacy RDA Grant for R&D
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=730011
• 关键词: Methodology; Producing; New; Heterocyclic; Building

Combinatorial chemistry is a technique by which large numbers of structurallydistinct molecules may be synthesised in a time and resource-effective manner, andthen submitted for pharmacological assay in a variety of forms. The key feature ofcombinatorial chemistry is that compound synthesis is designed such that a range ofanalogues can be produced using similar reaction conditions, either in the samereaction vessel, or individually in parallel using semi-automated synthesis. In thisway, the bench-chemist can single-handedly prepare many hundreds or thousands ofcompounds in the time usually taken to prepare only a few by orthodox methodology.Combinatorial chemistry is thus a major tool in the drug discovery process. Effectiveapplication of this technology requires the availability of a wide range of chemicalbuilding blocks with diverse structures.

组合化学是一种技术，通过该技术可以以时间和资源有效的方式合成大量结构不同的分子，然后以各种形式提交用于药理学测定。组合化学的关键特征是化合物合成的设计使得一系列类似物可以使用类似的反应条件来生产，无论是在同一反应容器中，还是使用半自动化合成单独平行生产。通过这种方式，实验室化学家可以在传统方法制备几种化合物所需的时间内，单独制备出成百上千种化合物。因此，组合化学是药物发现过程中的一个主要工具。该技术的连续应用需要具有不同结构的广泛的化学构建块的可用性。