Methodology for Producing New Heterocyclic Building Blocks for Drug Synthesis

组合化学是一种技术，通过这种技术，可以在时间和资源有效的方式下合成大量结构不同的分子，然后以各种形式提交药理学分析。组合化学的关键特征是，化合物合成的设计使得一系列类似物可以在相似的反应条件下生产，要么在同一反应容器中，要么在半自动合成中单独平行生产。用这种方法，一个初级化学家可以单凭一己之力制备数百或数千种化合物，而用传统的方法通常只需要制备几种化合物。因此，组合化学是药物发现过程中的主要工具。该技术的有效应用需要具有不同结构的广泛化学构建块的可用性。

Combinatorial chemistry is a technique by which large numbers of structurallydistinct molecules may be synthesised in a time and resource-effective manner, andthen submitted for pharmacological assay in a variety of forms. The key feature ofcombinatorial chemistry is that compound synthesis is designed such that a range ofanalogues can be produced using similar reaction conditions, either in the samereaction vessel, or individually in parallel using semi-automated synthesis. In thisway, the bench-chemist can single-handedly prepare many hundreds or thousands ofcompounds in the time usually taken to prepare only a few by orthodox methodology.Combinatorial chemistry is thus a major tool in the drug discovery process. Effectiveapplication of this technology requires the availability of a wide range of chemicalbuilding blocks with diverse structures.